No Benefit of Hemostatic Drugs on Acute Upper Gastrointestinal Bleeding in Cirrhosis.

BioMed Research International
Yang AnXingshun Qi

Abstract

Acute upper gastrointestinal bleeding (AUGIB) is one of the most life-threatening emergency conditions. Hemostatic drugs are often prescribed to control AUGIB in clinical practice but have not been recommended by major guidelines and consensus. The aim of this study was to investigate the therapeutic effect of hemostatic drugs on AUGIB in cirrhosis. All cirrhotic patients with AUGIB who were admitted to our hospital from January 2010 to June 2014 were retrospectively included. Patients were divided into hemostatic drugs and no hemostatic drug groups. A 1 : 1 propensity score matching (PSM) analysis was performed by adjusting age, gender, etiology of liver disease, Child-Pugh score, MELD score, hematemesis, red blood cell transfusion, vasoactive drugs, antibiotics, proton pump inhibitors, and endoscopic variceal therapy. Primary outcomes included 5-day rebleeding and in-hospital mortality. Overall, 982 cirrhotic patients with AUGIB were included (870 in hemostatic drugs group and 112 in no hemostatic drug group). In overall analyses, hemostatic drugs group had a significantly higher 5-day rebleeding rate (18.10% versus 5.40%, P = 0.001) than no hemostatic drug group; in-hospital mortality was not significantly different between ...Continue Reading

References

Apr 3, 2002·Seminars in Liver Disease·Lucio AmitranoAntonio Balzano
Apr 14, 2004·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·R de Franchis
Oct 14, 2004·Gastroenterology·Jaime BoschUNKNOWN European Study Group on rFVIIa in UGI Haemorrhage
Jun 1, 2005·Toxicon : Official Journal of the International Society on Toxinology·Neville Marsh, Vaughan Williams
Jan 18, 2007·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·I Q MolenaarR J Porte
Apr 9, 2008·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Jaime BoschUNKNOWN International Study Group on rFVIIa in UGI Hemorrhage
Mar 5, 2010·The New England Journal of Medicine·Guadalupe Garcia-Tsao, Jaime Bosch
Nov 10, 2012·World Journal of Gastroenterology : WJG·Norma C McAvoyPeter C Hayes
Aug 22, 2013·World Journal of Gastroenterology : WJG·Erwin Biecker
Nov 22, 2014·The Cochrane Database of Systematic Reviews·Cathy BennettLise Lotte Gluud
Apr 19, 2015·Gut·Dhiraj TripathiUNKNOWN Clinical Services and Standards Committee of the British Society of Gastroenterology
Jun 11, 2015·The Cochrane Database of Systematic Reviews·Arturo J Martí-Carvajal, Ivan Solà
Jun 11, 2015·The Cochrane Database of Systematic Reviews·Arturo J Martí-Carvajal, Ivan Solà
Jul 20, 2016·World Journal of Gastroenterology : WJG·Tao WangBang-Mao Wang
Feb 18, 2017·The International Journal of Pharmacy Practice·Ryan M RivosecchiHeather Johnson
Mar 7, 2017·Archives of Medical Science : AMS·Xingshun QiXiaozhong Guo
Mar 23, 2017·The American Journal of Case Reports·Hai-Bo Zhou
Oct 17, 2017·Translational Gastroenterology and Hepatology·Xingshun QiXiaozhong Guo
Nov 11, 2017·BMC Medicine·Annalisa Berzigotti
Mar 31, 2018·Journal of Gastroenterology and Hepatology·Parul TandonErin Kelly
Apr 7, 2018·Indian Journal of Hematology & Blood Transfusion : an Official Journal of Indian Society of Hematology and Blood Transfusion·Xu Linglong, Wu Dijiong
Sep 10, 2018·Indian Journal of Gastroenterology : Official Journal of the Indian Society of Gastroenterology·Ashok JhajhariaSandeep Nijhawan
Aug 12, 2019·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Antonio FacciorussoNicola Muscatiello

❮ Previous
Next ❯

Software Mentioned

Excel
SE
Stata
SPSS

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

The New England Journal of Medicine
P M Mannucci
Strasbourg médical
J P WEILL
Le Chirurgien-dentiste de France
J Saulnier
Zahnärztliche Rundschau
K JALOWICZ
Comprehensive Therapy
S J McPhee, W R Bell
© 2021 Meta ULC. All rights reserved