No changes in cerebrospinal fluid levels of nitrite, nitrate and cyclic GMP with aging. Short communication

Journal of Neural Transmission
K YamadaT Nabeshima

Abstract

Nitric oxide (NO) is a free radical gas that plays a role in various signal transduction processes. NO has been proposed to have a function in the mechanism of synaptic plasticity, including long-term potentiation and memory formation in vivo. Because a failure in synaptic plasticity is considered to be involved in aging-associated brain dysfunction, NO production in the brain may be altered by aging. In the present study, we measured the levels of NO metabolites, nitrite and nitrate, and cyclic GMP in the cerebrospinal fluid (CSF) of human subjects without neurological or psychiatric disorders. There were no age-related changes in the CSF levels of either nitrite, nitrate or cyclic GMP. These results suggest that NO production in the brain may be maintained during the aging process.

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Citations

Aug 27, 2005·The Kurume Medical Journal·Takuya WatanabeKensei Nagata
Nov 30, 2006·Brain, Behavior, and Immunity·Guillermo M AlexanderRobert J Schwartzman
Dec 8, 2004·Neurobiology of Aging·Nikolaos PitsikasEugenio E Muller
Nov 26, 1998·Microscopy Research and Technique·K Yamada, T Nabeshima
May 6, 2006·Nutrition Reviews·Steven H Zeisel, Mihai D Niculescu
Dec 6, 2006·The International Journal of Neuroscience·R ShuklaM Dikshit
Aug 23, 2020·Experimental Gerontology·Willian MargottiFabricia Petronilho

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