Abstract
Nitric oxide (NO) is a free radical gas that plays a role in various signal transduction processes. NO has been proposed to have a function in the mechanism of synaptic plasticity, including long-term potentiation and memory formation in vivo. Because a failure in synaptic plasticity is considered to be involved in aging-associated brain dysfunction, NO production in the brain may be altered by aging. In the present study, we measured the levels of NO metabolites, nitrite and nitrate, and cyclic GMP in the cerebrospinal fluid (CSF) of human subjects without neurological or psychiatric disorders. There were no age-related changes in the CSF levels of either nitrite, nitrate or cyclic GMP. These results suggest that NO production in the brain may be maintained during the aging process.
References
Oct 26, 1979·Science·J F Marshall, N Berrios
Jul 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·V L DawsonS H Snyder
Feb 1, 1991·Trends in Neurosciences·J Garthwaite
Dec 6, 1991·Science·E M Schuman, D V Madison
Nov 12, 1991·European Journal of Pharmacology·J P NowickiB Scatton
Nov 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·D S Bredt, S H Snyder
Jan 1, 1984·Neurobiology of Aging·F H GageA Björklund
Jul 30, 1982·Science·R T BartusA S Lippa
Jan 1, 1993·Journal of Neural Transmission. General Section·M Strolin BenedettiM Cini
Sep 23, 1994·Science·Z HuangM A Moskowitz
Oct 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·G A BöhmeJ C Blanchard
Jan 1, 1994·Life Sciences·T NabeshimaT Shohmori
Sep 1, 1994·Journal of Neurochemistry·S MilstienM P Heyes
Apr 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·V L DawsonS H Snyder
Jan 1, 1994·Journal of the Neurological Sciences·M A KuiperE C Wolters
Aug 21, 1995·Neuroreport·G A QureshiA Siden
Jul 1, 1995·British Journal of Pharmacology·K YamadaT Nabeshima
Apr 1, 1996·Journal of Neurochemistry·M SalterP J Strijbos
Jan 1, 1995·Journal of Neural Transmission. General Section·M IkedaS Murota
Mar 1, 1996·Neuroscience Research·K YamadaT Nabeshima
Sep 1, 1996·Neuroscience·K YamadaT Nabeshima
Mar 1, 1997·Journal of Neurochemistry·K Yamada, T Nabeshima
Jun 1, 1997·Neuroscience Research·K Yamada, T Nabeshima
Citations
Aug 30, 2000·Neuroscience Letters·W YuJ Cheng
May 23, 2000·Neuroscience Letters·H TohgiC Isobe
Aug 27, 2005·The Kurume Medical Journal·Takuya WatanabeKensei Nagata
Mar 22, 2008·Brain Research Bulletin·Yusuke OhgamiRaymond M Quock
Nov 30, 2006·Brain, Behavior, and Immunity·Guillermo M AlexanderRobert J Schwartzman
Jun 1, 2005·Journal of Neuroscience Methods·Xianjun WangNaoto Endo
Dec 8, 2004·Neurobiology of Aging·Nikolaos PitsikasEugenio E Muller
Mar 30, 2016·European Journal of Pharmacology·Naihao LuYi-Yuan Peng
Nov 26, 1998·Microscopy Research and Technique·K Yamada, T Nabeshima
May 6, 2006·Nutrition Reviews·Steven H Zeisel, Mihai D Niculescu
Aug 19, 2000·Oncogene·S SasakiM Yokoyama
Dec 6, 2006·The International Journal of Neuroscience·R ShuklaM Dikshit
Aug 23, 2020·Experimental Gerontology·Willian MargottiFabricia Petronilho