No compensatory upregulation of placental dimethylarginine dimethylaminohydrolase activity in preeclampsia

Gynecologic and Obstetric Investigation
Michiel P C SiroenPaul A M van Leeuwen

Abstract

Placental dysfunction of the asymmetric dimethylarginine (ADMA) degrading enzyme dimethylarginine dimethylaminohydrolase (DDAH) has been suggested as one of the initiating events in the development of preeclampsia (PE). Our primary aim was to investigate the role of the placenta in the metabolism of ADMA during normal pregnancy and PE. We studied 27 nonpregnant healthy women (C), 15 normotensive pregnant females (P), 16 patients with PE, and 7 patients with the 'hemolysis, elevated liver enzymes and low platelets' syndrome (H). There were no significant differences between P and PE with respect to fetomaternal gradient of ADMA, placental DDAH activity and placental ADMA content. During the first stage of labour, mean (+/-SD) plasma ADMA (micromol/l) was higher in H (0.69 +/- 0.22; p < 0.05) compared with C (0.44 +/- 0.07), P (0.37 +/- 0.06), and PE (0.40 +/- 0.06). ADMA was significantly associated with laboratory parameters of hepatic and renal function and with clinical parameters, including systolic and diastolic blood pressure, gestational age, birth weight, and placenta weight. A compensatory upregulation of placental DDAH activity is absent in patients suffering from PE and levels of ADMA in plasma and placenta are normal...Continue Reading

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Citations

Jul 20, 2006·Annual Review of Nutrition·Michiel P C SiroenPaul A M van Leeuwen
Jun 7, 2013·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Marzena LaskowskaJan Oleszczuk
Sep 27, 2012·Reproductive Sciences·Robert M EhsanipoorKenneth Chan
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Jan 31, 2012·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Maike AnderssohnRainer H Böger
Nov 1, 2008·JPEN. Journal of Parenteral and Enteral Nutrition·Milan C RichirPaul A M van Leeuwen
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Dec 15, 2010·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Marzena LaskowskaJan Oleszczuk
Oct 13, 2017·Clinica Chimica Acta; International Journal of Clinical Chemistry·Ei MarutaFumitaka Kikkawa
Aug 26, 2006·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Tom Teerlink

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