No contribution of ascorbic acid to renal calcium oxalate stones

Annals of Nutrition & Metabolism
H Gerster

Abstract

Even though a certain part of oxalate in the urine derives from metabolized ascorbic acid (AA), the intake of high doses of vitamin C does not increase the risk of calcium oxalate kidney stones due to physiological regulatory factor: gastrointestinal absorption as well as renal tubular reabsorption of AA are saturable processes, and the metabolic transformation of AA to oxalate is limited as well. Older assays for urinary oxalate favored in vitro conversion of AA to oxalate during storage and processing of the samples. Recurrent stone formers and patients with renal failure who have a defect in AA or oxalate metabolism should restrict daily vitamin C intakes to approximately 100 mg. But in the large-scale Harvard Prospective Health Professional Follow-Up Study, those groups in the highest quintile of vitamin C intake (> 1,500 mg/day) had a lower risk of kidney stones than the groups in the lowest quintiles.

Citations

Nov 27, 2004·Urological Research·Marguerite Hatch, Robert W Freel
Nov 27, 2008·The Journal of Alternative and Complementary Medicine : Research on Paradigm, Practice, and Policy·Fabien Deruelle, Bertrand Baron
Mar 13, 2003·Kidney International·Alessandra Calábria BaxmannIta Pfeferman Heilberg
Jul 11, 2003·The Journal of Urology·Olivier TraxerMargaret S Pearle
Dec 1, 2004·JPEN. Journal of Parenteral and Enteral Nutrition·Lourdes Peña de la VegaDarlene G Kelly
Feb 8, 2005·Integrative Cancer Therapies·Michael J GonzálezAngel Román-Franco
May 18, 2018·Integrative Cancer Therapies·Anthony J BazzanDaniel A Monti
Oct 23, 2004·Nephron. Physiology·Ph Jaeger, W G Robertson
Jul 14, 2020·Internal Medicine Journal·Adrian Jonathan SykesHarriet Cheng
Sep 11, 2018·Case Reports in Nephrology and Dialysis·Seiji HashimotoTakashi Shigematsu

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