PMID: 9437230Jan 23, 1998Paper

No correlation between insulin and islet amyloid polypeptide after stimulation with glucagon-like peptide-1 in type 2 diabetes

European Journal of Endocrinology
B Ahrén, M Gutniak

Abstract

To examine whether glucagon-like peptide-1 (GLP-1), which has been suggested as a new therapeutic agent in type 2 diabetes, affects circulating islet amyloid polypeptide (IAPP), a B-cell peptide of potential importance for diabetes pathophysiology. GLP-1 was administered in a buccal tablet (400 micrograms) to seven healthy subjects and nine subjects with type 2 diabetes. Serum IAPP and insulin levels were measured before and after GLP-1 administration. In the fasting state, serum IAPP was 4.1 +/- 0.3 pmol/l in the controls vs 9.8 +/- 0.9 pmol/l in the subjects with type 2 diabetes (P < 0.001). IAPP correlated with insulin only in controls (r = 0.74, P = 0.002) but not in type 2 diabetes (r = 0.26, NS). At 15 min after GLP-1, circulating IAPP increased to (6.0 +/- 0.5 pmol/l in controls P = 0.009) and to 13.8 +/- 1.2 pmol/l in type 2 diabetes (P = 0.021). In both groups, serum insulin increased and blood glucose decreased compared with placebo. In controls serum IAPP increased in parallel with insulin (r = 0.79, P = 0.032), whereas in type 2 diabetes the increase in IAPP did not correlate with the increase in insulin. Type 2 diabetes is associated with elevated circulating IAPP; GLP-1stimulates IAPP secretion both in healthy hum...Continue Reading

Citations

Oct 22, 1998·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·B Ahrén
Aug 7, 2012·Diabetes, Obesity & Metabolism·T A Lutz
Mar 1, 2008·Expert Opinion on Medical Diagnostics·Michael MarisChantal Mathieu
Sep 20, 2006·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Katsumichi Iki, Parviz M Pour
Jan 31, 2018·Journal of Molecular Endocrinology·Heather C Denroche, C Bruce Verchere
Nov 20, 2016·Temperature : Multidisciplinary Biomedical Journal·Shane K Maloney

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