No Cost of Complexity in Bacteriophages Adapting to a Complex Environment

Genetics
Andrew M Sackman, Darin R Rokyta

Abstract

A long-standing prediction in evolutionary biology is that organisms experience a so-called "cost of complexity" manifested as a decreasing rate of adaptation in populations as organisms or selective environments become increasingly complex. This theory assumes the ubiquity of antagonistic pleiotropy, or trade-offs in fitness, for mutations affecting multiple traits or phenotypes. A particular manifestation of antagonism thought to be at play in adaptive dynamics involves the relationship between viral growth rate and capsid stability, an interaction that may impede the adaptation of viral pathogens to novel hosts and environments. Here, we present a comparison of the genetics of adaptation for populations of bacteriophages undergoing complete adaptive walks under both simple and complex selective conditions, with complexity being determined by the number of traits under directional selection. We found no evidence for a long-term cost of complexity in viruses experiencing complex selection, with on average at least as great a rate of adaptation under more complex conditions, and rampant evidence for synergistic, rather than antagonistic, pleiotropy. The lack of evident trade-offs between multiple phenotypes implies that emergin...Continue Reading

References

Nov 1, 1985·Genetics·D L HartlA M Dean
Sep 11, 1980·Nature·M Rose, B Charlesworth
Jun 1, 2000·Molecular Biology and Evolution·J J BullH A Wichman
Aug 11, 2000·Evolution; International Journal of Organic Evolution·H A Orr
Jun 30, 2001·Evolution; International Journal of Organic Evolution·V S CooperR E Lenski
Sep 25, 2003·Evolution; International Journal of Organic Evolution·John J Welch, David Waxman
May 20, 2004·Proceedings of the National Academy of Sciences of the United States of America·R Craig MacLeanPaul B Rainey
Jun 24, 2004·Proceedings. Biological Sciences·Sarah P Otto
Oct 8, 2004·Nature·Kevin R FosterChris R L Thompson
Jan 13, 2005·Proceedings of the National Academy of Sciences of the United States of America·Jesse D BloomFrances H Arnold
Aug 3, 2005·Nature Reviews. Genetics·Mark A DePristoDaniel L Hartl
Sep 30, 2005·Journal of Molecular Recognition : JMR·Adam Zlotnick
Jan 24, 2006·Journal of Bacteriology·D R RokytaH A Wichman
Aug 1, 1949·Heredity·K MATHER, B J HARRISON
Mar 28, 2008·Nature·Günter P WagnerJames M Cheverud
May 9, 2008·PLoS Computational Biology·Nobuhiko TokurikiDan S Tawfik
Aug 21, 2009·Journal of Molecular Evolution·Darin R RokytaHolly A Wichman
Sep 22, 2009·Current Opinion in Structural Biology·Nobuhiko Tokuriki, Dan S Tawfik
Feb 19, 2011·Nature Reviews. Genetics·Günter P Wagner, Jianzhi Zhang
Mar 17, 2012·Molecular Ecology·Jill T AndersonThomas Mitchell-Olds
Nov 12, 2013·Genetics·S Brian CaudleDarin R Rokyta
Jan 1, 2009·Language Learning and Development : the Official Journal of the Society for Language Development·Daniel J WeissAaron D Mitchel
Jul 22, 2014·Molecular Ecology·Christopher G OakleyDouglas W Schemske
Aug 5, 2014·Current Opinion in Virology·Daniel H Goldhill, Paul E Turner
May 31, 2015·Molecular Biology and Evolution·Sarah M Doore, Bentley A Fane
Nov 14, 2015·Genetics·Lindsey W McGeeDarin R Rokyta
Sep 28, 2017·ELife·Angela M PhillipsMatthew D Shoulders
Nov 9, 2017·Genetics·Andrew M Sackman, Darin R Rokyta

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