No Difference in Ghrelin-Producing Cell Expression in Obese Versus Non-obese Stomach: a Prospective Histopathological Case-Control Study

Obesity Surgery
Mario MusellaFrancesco Paolo D'Armiento

Abstract

To understand the role of ghrelin in the mechanism of action of laparoscopic sleeve gastrectomy (LSG), a prospective cohort case-control study to assess the expression of ghrelin-producing cells (GPC) in two groups of patients was designed. Specimens of resected stomach from 26 obese patients who underwent LSG (group A), were compared by immunohistochemistry to control stomach samples from 26 non-obese patients (group B) resected for other pathologies or during autopsy; (GIST: 6 cases, inflammatory diseases: 4 cases, post-mortem autopsy cases with stomachs from healthy persons victims of traumatic accidents: 16 cases). Immunohistochemistry investigation was performed with the use of Ventana Benchmark ultra, anti-ghrelin antibody NOVUS, mouse monoclonal 2F4, diluted at 1:100. No significant difference in the expression of GPC number between group A and B was found (p = 0.87). No significant correlation between patients presenting a GPC number above (subgroup 1) or below (subgroup 2) the average, and EWL% changes, both at 1 and 6 years of follow-up, was recorded. Our study has shown that the expression of GPC is similar in the stomach of obese and non-obese controls, being mostly influenced by the inflammatory status of the gastr...Continue Reading

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Citations

Sep 5, 2020·Diabetes, Metabolic Syndrome and Obesity : Targets and Therapy·David Parada DDaniel Del Castillo
Nov 25, 2020·International Journal of Obesity : Journal of the International Association for the Study of Obesity·Sergio CastorinaSaverio Cinti
Aug 5, 2021·Surgery for Obesity and Related Diseases : Official Journal of the American Society for Bariatric Surgery·Nunzio VelottiMario Musella
Aug 28, 2021·Diagnostics·Irene Alexandra SpiridonIrina Draga Căruntu

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