PMID: 2494138Mar 1, 1989Paper

No difference in the nucleotide sequence of the DQ beta beta 1 domain between narcoleptic and healthy individuals with DR2,Dw2

Human Immunology
N UryuH Inoko

Abstract

Narcolepsy is a sleep disorder completely associated with HLA-DR2,Dw2. We demonstrated the 100% presence of three DQ beta fragments (EcoRI 2.4-kb, BamHI 2.9-kb, and PstI 12-kb) in narcoleptic patients that were detected in healthy DR2 controls only at decreased frequencies. In this paper, we have cloned the DQ beta gene from three Japanese narcoleptic patients and sequenced their beta 1 domain in order to study the sequence polymorphisms that might exist in the DQ beta genes of patients, but no difference in sequence could be found between narcoleptic and healthy individuals, suggesting that narcolepsy is not due to mutation in the DQ beta gene. In this context, a possible role of the HLA class II antigens in narcolepsy is discussed.

Citations

Jun 1, 1991·Trends in Neurosciences·M S Aldrich
Nov 1, 1993·Progress in Neurobiology·M S Aldrich
Aug 9, 1990·The New England Journal of Medicine·M S Aldrich
Jan 24, 1991·The New England Journal of Medicine
Apr 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·E MignotF C Grumet
Oct 25, 1989·Nucleic Acids Research
Oct 7, 2003·Annual Review of Genomics and Human Genetics·Dorothee ChabasEmmanuel Mignot
Jun 30, 2001·Journal of Neuroimmunology·L LinE Mignot
May 16, 2014·Immunologic Research·Emmanuel J M Mignot
Jan 1, 1995·Advances in Neuroimmunology·E MignotF C Grumet
Jan 13, 2006·International Review of Psychiatry·John Logan Black
May 20, 1998·Genome Research·H KadotaniE Mignot

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