No differences of immune activation and microbial translocation among HIV-infected children receiving combined antiretroviral therapy or protease inhibitor monotherapy

Medicine
Lola Falcon-NeyraLuis F Lopez-Cortes

Abstract

This is a cross-sectional study of 15 aviremic chronic HIV-infected children revealing no differences in immune activation (IA; HLA-DRCD38 CD4 and CD8 T cells, and sCD14) and microbial translocation (MT; lipopolysaccharides (LPS) and 16S rDNA) among HIV-infected patients under combined antiretroviral treatment (cART; n = 10) or ritonavir-boosted protease inhibitor monotherapy (mtPI/rtv; n = 5). In both cases, IA and MT were lower in healthy control children (n = 32). This observational study suggests that ritonavir boosted protease inhibitor monotherapy (mtPI/rtv) is not associated with an increased state of IA or MT as compared with children receiving cART.

References

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Citations

May 18, 2016·The Journal of Infectious Diseases·Andrew J PrendergastUNKNOWN ARROW Trial Team
May 27, 2016·Medicine·Ambili Nair PananghatKalpana Luthra
Sep 15, 2016·The Pediatric Infectious Disease Journal·Allison Ross EckardGrace A McComsey
Feb 13, 2018·Journal of the International AIDS Society·Alicia Gutierrez-ValenciaLuis F López-Cortés

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Methods Mentioned

BETA
flow cytometry
ELISA

Software Mentioned

SPSS
CellQuest

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