No direct role for A1/A2 adenosine receptor activation to reflex cutaneous vasodilatation during whole-body heat stress in humans

Acta Physiologica
Sarah M Fieger, B J Wong

Abstract

The precise mechanisms underlying reflex cutaneous vasodilatation during hyperthermia remain unresolved. The purpose of this study was to investigate a potential contribution of adenosine A1/A2 receptor activation to reflex cutaneous vasodilatation. Eight subjects were equipped with four microdialysis fibres on the left forearm, and each fibre was randomly assigned one of four treatments: (1) lactated Ringer's (control); (2) 4 mm of the non-selective A1/A2 adenosine receptor antagonist theophylline; (3) 10 mm L-NAME to inhibit nitric oxide (NO) synthase; and (4) combined 4 mm theophylline and 10 mm L-NAME. Laser-Doppler flowmetry (LDF) was used as an index of skin blood flow, and blood pressure was measured beat-by-beat via photoplethysmography and verified via brachial auscultation. Whole-body heat stress to raise oral temperature 0.8 °C above baseline was induced via water-perused suits. Cutaneous vascular conductance (CVC) was calculated as LDF/mean arterial pressure and normalized to maximal (%CVC max) via infusion of 28 mm nitroprusside and local heating to 43 °C. There was no difference between control (65 ± 5%CVC max) and theophylline (63 ± 5%CVC max) sites. L-NAME (44 ± 4%CVC max) and theophylline + L-NAME (32 ± 3%CVC m...Continue Reading

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Citations

Apr 2, 2014·The Journal of Physiology·Ryan McGinnGlen P Kenny
Feb 7, 2013·Acta Physiologica·P B Persson, A Bondke Persson
May 8, 2014·Acta Physiologica·A Bondke Persson, P B Persson
Jul 22, 2014·Acta Physiologica·A Bondke Persson, P B Persson
Oct 31, 2017·Clinical Physiology and Functional Imaging·Brett J WongErica L Levitt
Feb 15, 2013·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Brett J Wong
Oct 9, 2014·Physiological Reports·Ryan McGinnGlen P Kenny
Mar 30, 2017·Temperature : Multidisciplinary Biomedical Journal·Brett J Wong, Casey G Hollowed

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