NO-donors. Part 17: Synthesis and antimicrobial activity of novel ketoconazole-NO-donor hybrid compounds

Bioorganic & Medicinal Chemistry
Joerg KonterJochen Lehmann

Abstract

Novel hybrid compounds combining the antifungal drug ketoconazole with a diazen-1-ium-1,2-diolate or an organic nitrate moiety and the corresponding NO-donors without ketoconazole were synthesized and their activities against a broad variety of fungal strains were tested. Hybridization modifies the spectrum of antimicrobial activities and generally, the ketoconazole-NO-donor hybrids are more potent than ketoconazole. The NO-donors alone show insufficient effectiveness.

References

Nov 1, 1982·Antimicrobial Agents and Chemotherapy·M A PfallerD J Krogstad
Nov 13, 2003·Chembiochem : a European Journal of Chemical Biology·Sergii AfoninAnne S Ulrich

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Citations

May 2, 2012·Virulence·David O SchairerAdam J Friedman
Oct 30, 2016·Bioorganic & Medicinal Chemistry Letters·Benjamin E BlassMahesh Yanamandra
May 2, 2009·Bioorganic & Medicinal Chemistry Letters·Kathrin LangeJochen Lehmann

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