No effect of an elevated miR-30b level in mouse milk on its level in pup tissues.

RNA Biology
Johann LaubierFabienne Le Provost

Abstract

Recent reports have shown that ingested microRNAs may be transferred to blood, accumulate in tissues and exert canonical regulation on endogenous transcripts. In spite of several attempts to replicate these findings, they have not been confirmed and several questions remain. By using a transgenic mouse model presenting a high level of miR-30b in milk, the horizontal delivery of this microRNA via oral ingestion was studied in pups. Our findings demonstrated that, although very high levels of miR-30b were found in milk and in stomach contents of the pups, we did not detect an increase in miR-30b in tissues of pups fed by transgenic females compared to pups fed by wild-type females.

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Citations

Jun 23, 2016·Nutrition & Metabolism·Bodo C MelnikGerd Schmitz
Oct 30, 2016·RNA Biology·Kenneth W Witwer, Marc K Halushka
May 10, 2016·F1000Research·Amanda AuerbachKenneth Witwer
Oct 5, 2018·Annual Review of Animal Biosciences·Janos ZempleniEzra Mutai
Sep 22, 2017·Diseases·Bodo C Melnik, Gerd Schmitz
Nov 6, 2018·Frontiers in Pediatrics·Clair-Yves Boquien
Oct 1, 2020·PeerJ·Fermín Mar-AguilarDiana Reséndez-Pérez
Jul 12, 2017·Genes & Nutrition·Kenneth W Witwer, Chen-Yu Zhang
Nov 3, 2017·Physiological Genomics·Y ChenT Casey
Aug 5, 2015·The Journal of Biological Chemistry·Alexandra C TitleMarkus Stoffel
Sep 12, 2019·American Journal of Physiology. Gastrointestinal and Liver Physiology·Fang ZhouJanos Zempleni
May 1, 2019·Comprehensive Reviews in Food Science and Food Safety·Abderrahim Benmoussa, Patrick Provost
Oct 15, 2020·Nutrients·Elena Carrillo-LozanoCarolina Knott-Torcal
May 23, 2021·Advances in Nutrition·Christine LerouxJ Bruce German
Jun 1, 2021·Frontiers in Immunology·Cristina KalbermatterStephanie C Ganal-Vonarburg

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Methods Mentioned

BETA
transgenic
biopsies
PCR
Assay

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