No effect of B vitamins on ADMA levels in patients at increased cardiovascular risk

Clinical Endocrinology
A M E Spoelstra-de ManY M Smulders

Abstract

Asymmetric dimethylarginine (ADMA) is a recently identified potent cardiovascular risk factor. ADMA levels are increased in hyperhomocysteinaemia and the metabolism of ADMA is linked with that of homocysteine in several ways. Treatment with B vitamins effectively reduces homocysteine levels, but studies investigating the effect on ADMA levels are scarce and show conflicting results. In this study we evaluated the effect of treatment with B vitamins on ADMA levels in two high cardiovascular risk populations. In study I, 110 siblings of patients with clinical atherosclerotic disease and postmethionine hyperhomocysteinaemia were treated with 5 mg of folic acid and 250 mg of pyridoxine or placebo, and were analysed after 1 year. In study II, 41 patients with type 2 diabetes and mild hyperhomocysteinaemia were analysed after 6 months treatment with 5 mg of folic acid or placebo. A correlation between baseline homocysteine and ADMA levels was found, which was partly due to confounding by renal function. Homocysteine levels decreased by 43% in study I and by 28% in study II. In both studies, treatment with B vitamins had no effect at all on ADMA, arginine/ADMA ratio and SDMA levels. This result was confirmed in multiple linear regress...Continue Reading

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Citations

Apr 8, 2011·Amino Acids·Nele KanzelmeyerThomas Lücke
Aug 24, 2013·BMC Endocrine Disorders·Tarek Mk MotawiMohamed O Mahmoud
Oct 17, 2007·Clinical Chemistry and Laboratory Medicine : CCLM·Coen van GuldenerCoen D A Stehouwer
Sep 13, 2008·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Prabath W B NanayakkaraYvo M Smulders
Apr 10, 2012·Atherosclerosis·Monica S RochaHenk J Blom
Mar 30, 2011·Nature Reviews. Nephrology·Edzard Schwedhelm, Rainer H Böger

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