No effect of group-based aerobic interval training on N-terminal pro- B-type natriuretic peptide levels in patients with chronic heart failure

Scandinavian Cardiovascular Journal : SCJ
Birgitta Blakstad NilssonIngebjørg Seljeflot

Abstract

Exercise training might improve cardiac function as well as functional capacity in patients with chronic heart failure (CHF). N-terminal pro-B-type natriuretic peptide (NT pro-BNP), is associated with the severity of the disease, and has been reported to be an independent predictor of outcome in CHF. We evaluated the effect of a four months group-based aerobic interval training program on circulating levels of NT pro-BNP in patients with CHF. We have previously reported improved functional capacity in 80 patients after exercise in this exercise program. Seventy-eight patients with stable CHF (21% women; 70+/-8 years; left ventricular ejection fraction 30+/-8.6%) on optimal medical treatment were randomized either to interval training (n=39), or to a control group (n=39). Circulating levels of NT pro-BNP, a six minute walk test (6MWT) and cycle ergometer test were evaluated at baseline, post exercise, and further after 12 months. There were no significant differences in NT pro-BNP levels from baseline to either post exercise or long-term follow-up between or within the groups. Inverse correlations were observed between NT pro-BNP and 6MWT (r=-0.24, p=0.035) and cycle exercise time (r=-0.48, p<0.001) at baseline. But no significa...Continue Reading

References

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Citations

Feb 12, 2013·Current Heart Failure Reports·Philippe MeyerAnil Nigam
Aug 13, 2011·Scandinavian Journal of Clinical and Laboratory Investigation·Rune ByrkjelandIngebjørg Seljeflot
Nov 22, 2011·International Journal of Cardiology·Neil A SmartFrancesco Giallauria
Dec 6, 2011·American Heart Journal·Philip Samuel OsbakGorm Boje Jensen
Jun 22, 2019·Scandinavian Cardiovascular Journal : SCJ·Xavier MeloHelena Santa-Clara
Jun 15, 2012·Sports Medicine·Thibaut GuiraudLaurent Bosquet

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