No Effect of High-Dose Vitamin D Treatment on β-Cell Function, Insulin Sensitivity, or Glucose Homeostasis in Subjects With Abnormal Glucose Tolerance: A Randomized Clinical Trial

Diabetes Care
Henrik WagnerClaes-Göran Östenson

Abstract

There has been conflicting evidence regarding the potential role of vitamin D in glucose homeostasis. This study was designed to investigate the effect of high-dose vitamin D3 treatment on β-cell function, insulin sensitivity, and glucose tolerance in subjects with prediabetes or diet-treated type 2 diabetes. Subjects (n = 44) were randomized to 30,000 IU vitamin D3 once weekly or placebo for 8 weeks. Hyperglycemic clamp assessed first-phase (0-12 min) and second-phase (12-120 min) insulin response, insulin sensitivity, and disposition index (DI). An oral glucose tolerance test assessed glucose tolerance and glycosylated hemoglobin assessed glycemic control. A total of 21 (vitamin D) and 22 (placebo) subjects completed the study, respectively. Season-adjusted 25-OH-vitamin D [25(OH)D] levels were doubled in the active treated group (43-82 nmol/L). No effect of vitamin D treatment, compared with placebo, was seen on first-phase or second-phase insulin secretion. There were no group differences in insulin sensitivity, DI, or any measures of glycemic control. No hypercalcemia or other adverse effects of vitamin D treatment were seen compared with placebo. Subgroup analyses of those with the lowest basal and greatest increase in 25...Continue Reading

References

Nov 1, 1990·Experimental and Clinical Endocrinology·I Zofková, P Stolba
May 1, 1994·The American Journal of Clinical Nutrition·E OrwollM Prince
Jul 1, 1997·European Journal of Clinical Investigation·D FliserE Ritz
Mar 29, 2007·The Journal of Clinical Endocrinology and Metabolism·Anastassios G PittasBess Dawson-Hughes
Jul 14, 2007·Diabetes Care·Catharina MattilaAntti Reunanen
Feb 1, 2008·Diabetes Care·Ian H de BoerUNKNOWN Women's Health Initiative Investigators
Jun 3, 2008·Diabetic Medicine : a Journal of the British Diabetic Association·A-K ErikssonC-G Ostenson
Jul 26, 2008·Nutrition·Kamilia TaiIan M Chapman
Jun 30, 2011·International Journal of Obesity : Journal of the International Association for the Study of Obesity·C C M MoorsG H Goossens
Jan 26, 2012·Diabetes·Mustafa KanatMuhammad A Abdul-Ghani
Oct 4, 2012·Diabetes Care·Mayer B DavidsonTheodore C Friedman

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Citations

May 10, 2017·Endocrinology·Edith Angellotti, Anastassios G Pittas
Jun 1, 2018·International Journal of Molecular Sciences·Meenakshi UmarAouatef I Chouchane
Apr 12, 2018·Archives of Endocrinology and Metabolism·Preneet Cheema BrarNipapat Visavachaipan
Aug 24, 2018·The Journal of Clinical Endocrinology and Metabolism·Adriyan PramonoEllen E Blaak
Mar 12, 2019·International journal for vitamin and nutrition research. Internationale Zeitschrift für Vitamin- und Ernährungsforschung. Journal international de vitaminologie et de nutrition·Kaustubh Bora, Alice Abraham Ruram
Jan 12, 2019·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Qiaorui LiuLing Qiu
Jun 21, 2019·Journal of Diabetes·Jian-Min LiuUNKNOWN Chinese Society of Osteoporosis and Bone Mineral Research, the Chinese Society of Endocrinology, Chinese Diabetes Society, C
Jan 17, 2019·Cardiovascular & Hematological Disorders Drug Targets·Y DurgaraoM S Rukmini
Oct 3, 2020·Nutrients·Jun Wern YauAmutha Ramadas
Nov 20, 2016·Journal of the American Geriatrics Society·Silvina Levis, Orlando Gómez-Marín
Mar 20, 2019·Nutrients·Araceli Muñoz-GarachManuel Muñoz-Torres
Jun 20, 2021·BMC Pregnancy and Childbirth·Chun YangWenguang Sun

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