Abstract
HLA-C mismatch in unrelated donor's hematopoietic stem cell transplantation (HSCT) has been associated with poor patient outcome. However, the impact of HLA-C mismatch in the context of HSCT combined with in vivo T-cell depletion remains unclear. We therefore performed a single-center, retrospective analysis of the clinical outcome on patients with hematological malignancies treated with allo-HSCT, who underwent T-cell depletion. The majority of the patients (n=276) received a HLA-A, HLA-B, HLA-DRB1-matched graft that were either also HLA-C matched (n=260), or patients with the permissive HLA-C*03:03/03:04 mismatch (n=16), while the remaining patients (n=95) received a HLA-C-mismatched graft (excluding HLA-C*03:03/03:04 mismatches). We did not observe any significant differences between the HLA-C-matched patients (including the permissive HLA-C*03:03/03:04 mismatch) and the HLA-C-mismatched patients regarding cumulative proportion surviving, graft failure, relapse-free survival, relapse, or acute graft-versus-host disease. Our data suggest that in the context of high dose T lymphocyte-depleting agents, HLA-C matching is not essential for patients with hematological malignancies.
References
Oct 22, 1998·The New England Journal of Medicine·T SasazukiF Takaku
Apr 16, 1999·Statistics in Medicine·T A GooleyB E Storer
May 16, 2002·Blood·Yasuo MorishimaYoshihisa Kodera
Sep 6, 2003·Tissue Antigens·M SchafferO Olerup
Apr 21, 2007·Tissue Antigens·E W PetersdorfUNKNOWN International Histocompatibility Working Group in Hematopoietic Cell Transplantation
Jul 21, 2007·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Pascale LoiseauColette Raffoux
Mar 17, 2009·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Nicolaus KrögerAxel Zander
Apr 8, 2010·Blood·Adam J MeadKarl S Peggs
Jun 19, 2010·The Lancet Oncology·Mary EapenUNKNOWN National Cord Blood Program of the New York Blood Center
Sep 28, 2010·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Ann WoolfreyStephanie J Lee
Apr 6, 2013·Science·Richard AppsMary Carrington
Jun 7, 2014·Frontiers in Immunology·Jean-Marie Tiercy
Jun 10, 2015·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Michael R VernerisJohn Koreth