No effect of homocysteine-lowering therapy on vascular inflammation and haemostasis in peripheral arterial occlusive disease

European Journal of Clinical Investigation
G-H SchernthanerG Schernthaner

Abstract

Although peripheral arterial occlusive disease (PAOD) is significantly associated with elevated homocysteine levels, the clinical relevance of hyperhomocysteinaemia for the prevention and progression of PAOD is still unknown. A total of 65 patients suffering from symptomatic PAOD with elevated homocysteine levels were randomized onto placebo or B-vitamins (50 mg thiaminhydrochlorid, 50 mg pyridoxine, and 0.05 mg cyanocobalamin), plus 5 mg folic acid daily for 6 weeks. Serum levels of folic acid, vitamin B12, creatinine, ultra-sensitive C-reactive protein (usCRP), interleukin (IL)-6, IL-8, IL-18, monocyte-chemo-attractant-protein-1 (MCP-1) and plasma levels of homocysteine, tissue factor (TF) and tissue factor pathway inhibitor (TFPI) were determined on the 1st day and 42nd day. Primary outcome was reduction of homocysteine, secondary outcomes were reduction of usCRP, IL-6, IL-8, Il-18, MCP-1, TF and TFPI. The mean reduction of homocysteine concentration was 33% (95%CI 33.36-55.76, or 18.9+/-5.4 micromol L-1-12.6+/-2.8 micromol L-1, P=0) in the B-vitamin group compared with 1% in the placebo group. Folic acid (P=0) and vitamin B12 (P=0) increased significantly in the verum group, but both remained unchanged in the control group....Continue Reading

References

Mar 1, 1992·Journal of Internal Medicine·J MölgaardA G Olsson
Oct 4, 1995·JAMA : the Journal of the American Medical Association·C J BousheyA G Motulsky
Jun 11, 1997·JAMA : the Journal of the American Medical Association·I M GrahamG Andria
Nov 14, 1997·Arteriosclerosis, Thrombosis, and Vascular Biology·R W EvansL H Kuller
Nov 14, 1997·Arteriosclerosis, Thrombosis, and Vascular Biology·A MajorsE H Pezacka
Jan 29, 2002·The American Journal of Medicine·Judith G Regensteiner, William R Hiatt
May 17, 2003·Stroke; a Journal of Cerebral Circulation·Una B FallonGeorge Davey Smith
Jan 21, 2004·Biochimica Et Biophysica Acta·Emi NakanoHilary J Powers
Mar 11, 2004·Journal of Thrombosis and Haemostasis : JTH·V E A GerdesUNKNOWN Amsterdam Vascular Medicine Group
Mar 31, 2004·Circulation·Joseph A CapriniKaren Hathaway
Jun 4, 2004·Journal of Endovascular Therapy : an Official Journal of the International Society of Endovascular Specialists·Tamara KovacevicRenate Koppensteiner
Dec 17, 2004·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Lars M RasmussenThomas Ledet
Jan 7, 2005·The Journal of Clinical Endocrinology and Metabolism·Sophie ZieglerGerit-Holger Schernthaner
Apr 13, 2005·Autoimmunity Reviews·Min Chen, Anna von Mikecz
Jun 29, 2005·Archives of Internal Medicine·Jane DurgaPetra Verhoef
Jul 9, 2005·Arteriosclerosis, Thrombosis, and Vascular Biology·Jürgen HetzelNikolaus Marx
Aug 6, 2005·Clinical Biochemistry·Elmar ThyzelKnut Kleesiek
Aug 17, 2005·Journal of Thrombosis and Haemostasis : JTH·S R Lentz

❮ Previous
Next ❯

Citations

Dec 8, 2007·Eye·A D WrightP M Dodson
Aug 13, 2009·The British Journal of Surgery·N KhandanpourF J Meyer
Oct 25, 2006·Journal of Thrombosis and Haemostasis : JTH·C A RodriguesD M Lourenço
Jun 30, 2009·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·N KhandanpourM P Armon
Jul 31, 2009·Postgraduate Medicine·Herbert Aronow, William R Hiatt
Mar 22, 2014·The Journal of Nutrition·Clare AbbenhardtCornelia M Ulrich
Nov 10, 2007·Clinical Chemistry and Laboratory Medicine : CCLM·Anna Maria GoriRosanna Abbate
Feb 9, 2008·The American Journal of Clinical Nutrition·Paraskevi DetopoulouChristodoulos Stefanadis

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood Clotting Disorders

Thrombophilia includes conditions with increased tendency for excessive blood clotting. Blood clotting occurs when the body has insufficient amounts of specialized proteins that make blood clot and stop bleeding. Here is the latest research on blood clotting disorders.