PMID: 15389124Sep 25, 2004Paper

No effect of the prothrombin G20210A mutation on protein C activation in a large kindred with type I protein C deficiency

Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis
Carla Y VossenEdwin G Bovill

Abstract

Previously, we observed a positive association of prothrombin concentrations with thrombin generation (fragment 1 + 2) and thrombin activity (fibrinopeptide A), but no association with protein C activation peptide levels. We further evaluated a potential beneficial effect of increased prothrombin concentrations on activated protein C generation by assessing the plasma concentration of activated protein C in complex with protein C inhibitor (APC-PCI). Blood samples were used from 195 family members of a large French-Canadian kindred with type I protein C deficiency due to a 3363C insertion in the protein C gene. We utilized a new and highly sensitive assay for measuring the concentration of APC-PCI complex as a measure of the level of activation of protein C. Means of the plasma concentrations of the APC-PCI complex were compared among carriers and non-carriers of the prothrombin G20210A mutation. Protein C activity levels were positively associated with APC-PCI complex plasma concentrations; however, APC-PCI complex levels were not different for carriers of the prothrombin G20210A mutation than for non-carriers. Thus, carriers of the prothrombin G20210A mutation do not have increased protein C activation despite the increased t...Continue Reading

References

Oct 15, 1987·The New England Journal of Medicine·J MiletichG Broze
Apr 1, 1984·Seminars in Thrombosis and Hemostasis·K Suzuki
Nov 1, 1981·The Journal of Clinical Investigation·J H GriffinC Wideman
Jul 21, 1998·Annals of Internal Medicine·M MargaglioneG Di Minno
Jul 31, 1998·American Journal of Human Genetics·S J HasstedtG L Long
Aug 26, 1998·Arteriosclerosis, Thrombosis, and Vascular Biology·P A KyrleS Eichinger

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Citations

Jan 30, 2009·Haemophilia : the Official Journal of the World Federation of Hemophilia·S SchulmanJ Stenflo
Jun 18, 2005·The British Journal of Radiology·Y P ChoS G Lee
Aug 18, 2009·Blood Reviews·Charles T Esmon

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