No effects of human ghrelin on cardiac function despite profound effects on body composition in a rat model of heart failure

International Journal of Cardiology
Yoshihiro J AkashiJochen Springer

Abstract

Ghrelin, was observed to have treatment-potential for severe chronic heart failure (CHF) and cardiac cachexia based on anti-cachectic and cardio-protective effects. We performed two studies to assess the effects of human ghrelin on food intake, body weight and body composition, as well as heart function in a rat model of CHF. Study-1 (50 or 500 nmole/kg/d ghrelin by pump infusion) was focused on food intake and body composition, study-2 (50 or 100 nmole/kg/d ghrelin by subcutaneous injection (3-times daily) was focused on heart function due to a lack of cardiac effects observed in study-1. In both studies, myocardial infarction was induced by LAD ligation. On day 28 after surgery, rats were randomized and treated with ghrelin or placebo for 4 weeks. Food intake (study-1), body composition (NMR) cardiac function (echocardiography and invasive hemodynamics (study-2 only) were assessed. In study-1, CHF rats treated with high dose ghrelin showed an increase in body weight (+25%, p<0.001), lean mass (+16%, p<0.01) and fat mass (+17%, p=0.001) vs placebo. In study-2, CHF rats treated with both low- and high dose ghrelin showed an increase in body weight (both +18%, p</=0.001), lean mass (both +25%, p<0.001) and fat mass (50 nmole/kg/...Continue Reading

References

Dec 19, 1998·European Heart Journal·J IsgaardB A Bengtsson
Feb 15, 2003·Endocrinology·Kichoon ChoiShin-Ichi Sasaki
Jun 2, 2005·The International Journal of Biochemistry & Cell Biology·Sabine StrassburgStefan D Anker
Dec 8, 2005·Current Heart Failure Reports·Yoshihiro J AkashiStefan D Anker
Jan 28, 2006·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·Matthew J Delano, Lyle L Moldawer
Feb 7, 2006·Pharmacology, Biochemistry, and Behavior·Annika ThorsellCindy L Ehlers
Nov 18, 2006·Endocrinology·Elena GrossiniGiovanni Vacca
Dec 3, 2008·International Journal of Cardiology·Andrew J S Coats

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Citations

Aug 25, 2010·Current Opinion in Supportive and Palliative Care·Stephanie M Krasnow, Daniel L Marks
Nov 25, 2011·Journal of Veterinary Internal Medicine·L M Freeman
Aug 23, 2012·Nutrition & Metabolism·Mireia OlivanJosep M Argilés
Jul 25, 2014·Regulatory Peptides·Ming-Jie YuanCong-Xin Huang
Aug 28, 2010·International Journal of Peptides·Johannes D Veldhuis, Cyril Y Bowers
Nov 12, 2013·International Journal of Cardiology·Yulia ElkinaJochen Springer
Nov 6, 2012·International Journal of Cardiology·Jochen SpringerStefan D Anker
Oct 11, 2011·International Journal of Cardiology·Goran LoncarVera Popovic
Aug 9, 2011·Archives of Medical Research·Thaís de Oliveira FariaIvanita Stefanon
Apr 1, 2011·International Journal of Cardiology·Hirofumi RokutanJochen Springer
May 26, 2009·Peptides·Xiao-Ying DongXiao-Ting Zou
Jun 5, 2015·Molecular Metabolism·T D MüllerM H Tschöp
Sep 19, 2012·Journal of Cachexia, Sarcopenia and Muscle·Karsten LenkVolker Adams
Apr 9, 2011·Journal of Cachexia, Sarcopenia and Muscle·Theodore P Braun, Daniel L Marks
May 9, 2012·International Journal of Experimental Pathology·Milan Holecek
Nov 26, 2013·Journal of Cachexia, Sarcopenia and Muscle·Mareike S PötschJochen Springer
Jul 3, 2015·Journal of Cachexia, Sarcopenia and Muscle·Masaaki KonishiJochen Springer
Aug 30, 2014·Journal of Cachexia, Sarcopenia and Muscle·Míriam ToledoJosep M Argilés
Jun 12, 2013·International Journal of Cardiology·Jochen SpringerWolfram Doehner
May 18, 2013·International Journal of Cardiology·Sandra PalusJochen Springer
May 31, 2016·International Journal of Cardiology·Masakazu SaitohJochen Springer
Dec 30, 2009·Pharmacological Reviews·Chih-Yen ChenAkio Inui
Dec 24, 2010·Current Opinion in Endocrinology, Diabetes, and Obesity

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