No efficacy of transcranial direct current stimulation on chronic migraine with medication overuse: A double blind, randomised clinical trial.

Cephalalgia : an International Journal of Headache
Licia GrazziGiuseppe Lauria

Abstract

Transcranial direct current stimulation was suggested to provide beneficial effects in chronic migraine, a condition often associated with medication overuse for which no long-term therapy is available. We conducted a randomised controlled trial to assess long-term efficacy of transcranial direct current stimulation. Adults diagnosed with chronic migraine and medication overuse were assigned to receive in a 1:1:1 ratio anodal, cathodal, or sham transcranial direct current stimulation daily for five consecutive days, along with standardised drug withdrawal protocol. Primary outcome was 50% reduction of days of headache per month at 12 months. Co-secondary outcomes were 50% reduction of days of headache per month at 6 months, reduction of analgesic intake per month, and change in disability and quality of life, catastrophising, depression, state and trait anxiety, dependence attitude and allodynia intensity. Patients were not allowed to take any migraine prophylaxis drug for the entire study period. We randomly allocated 135 patients to anodal (44), cathodal (45), and sham (46) transcranial direct current stimulation. At 6 and 12 months, the percentage of reduction of days of headache and number of analgesics per month ranged bet...Continue Reading

Associated Clinical Trials

References

Oct 18, 2013·Frontiers in Human Neuroscience·Helena KnotkovaRicardo A Cruciani
Oct 23, 2013·The Journal of Headache and Pain·Paolo MartellettiUNKNOWN European Headache Federation
Mar 26, 2014·BMJ : British Medical Journal·Todd J Schwedt
May 29, 2015·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·L GrazziG Bussone
Jul 1, 2015·Cephalalgia : an International Journal of Headache·Chia-Chun ChiangDavid W Dodick
Nov 21, 2016·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Jean-Pascal LefaucheurWalter Paulus
Jun 2, 2017·Journal of the Neurological Sciences·Suellen Marinho AndradeBernardino Fernández-Calvo
Oct 21, 2017·Cephalalgia : an International Journal of Headache·Louise Ninett CarlsenLars Bendtsen
Mar 31, 2018·Neurological Research·Mírian Celly Medeiros Miranda DavidCarlúcia Ithamar Fernandes Franco
Jun 9, 2019·Lancet Neurology·Hans-Christoph DienerTodd Schwedt

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Citations

Jan 6, 2021·International Journal of Environmental Research and Public Health·Domenico D'AmicoAlberto Raggi
Dec 4, 2020·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·R De IccoC Tassorelli
Feb 11, 2021·International Journal of Environmental Research and Public Health·Licia GrazziErika Guastafierro
Jun 1, 2021·Neuromodulation : Journal of the International Neuromodulation Society·Tuba Cerrahoğlu ŞirinBetül Baykan
May 19, 2021·Neurology India·Joseph LloydGiorgio Lambru
Feb 8, 2022·Current Pain and Headache Reports·Gianluca CoppolaMariano Serrao

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