NO-ERGIC CONTROL OF BLOOD CIRCULATION IN THE MEDULLA OBLONGATA OF RATS WITH EXPERIMENTAL HEMIPARKINSONIZM UNDER EXPOSURE TO CONTINUOUS LIGHT

Fiziolohichnyĭ zhurnal
L M ShapovalV F Sagach

Abstract

The study was conducted on rats with unilateral damage to dopaminergic (DA) neurons in substantia nigra of the midbrain (experimental hemiparkinsonism). Degeneration of dopaminergic (DA) neurons was accompanied by hyperactivity of those neurons that remained intact and responded to apomorphine (Apo) test by rotational movements. Depending on the number of rotations, three groups of animals were defined. In the medulla oblongata of rats with unilateral damage to dopaminergic (DA) neurons, a significant increase in the activity of inducible NO-synthase (iNOS) was observed, while the activity of constitutive NO-synthase (cNOS) tended to decrease compared with that in control rats. An activation of neuronal NO-synthase (nNOS) in those rats by injections of L-arginine in the medullary nuclei was accompanied by weakening of the hemodynamic effects compared to those in control rats. An exposure of animals to continuous light for three weeks was accompanied by increasing the number of damaged DA-ergic neurons in substantia nigra. At that, a significant decrease in cNOS activity in the medulla oblongata was observed, leading to the inhibition of de novo synthesis of nitric oxide (NO). The reduction of NO synthesis in the medulla oblonga...Continue Reading

References

Oct 28, 1991·Neuroscience Letters·L N ShapovalL S Pobegailo
Dec 1, 1968·European Journal of Pharmacology·U Ungerstedt
May 21, 1998·European Journal of Pharmacology·S DoolenS P Duckles
Jul 17, 1999·Brain Research. Brain Research Reviews·T L Krukoff
Feb 26, 2000·Cardiovascular Research·J Zanzinger
Oct 22, 2003·Pathophysiology : the Official Journal of the International Society for Pathophysiology·P DobsakJ E. Wolf
Apr 19, 2005·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·Christiane MagerkurthStefan Braune
May 10, 2006·Journal of Endocrinological Investigation·S AydoganA Goktas
Oct 10, 2014·International Journal of Molecular Sciences·Olga PechanovaFedor Simko

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