No Escaping the Rat Race: Simulated Night Shift Work Alters the Time-of-Day Variation in BMAL1 Translational Activity in the Prefrontal Cortex

Frontiers in Neural Circuits
Andrea R MartiJanne Grønli

Abstract

Millions of people worldwide work during the night, resulting in disturbed circadian rhythms and sleep loss. This may cause deficits in cognitive functions, impaired alertness and increased risk of errors and accidents. Disturbed circadian rhythmicity resulting from night shift work could impair brain function and cognition through disrupted synthesis of proteins involved in synaptic plasticity and neuronal function. Recently, the circadian transcription factor brain-and-muscle arnt-like protein 1 (BMAL1) has been identified as a promoter of mRNA translation initiation, the most highly regulated step in protein synthesis, through binding to the mRNA "cap". In this study we investigated the effects of simulated shift work on protein synthesis markers. Male rats (n = 40) were exposed to forced activity, either in their rest phase (simulated night shift work) or in their active phase (simulated day shift work) for 3 days. Following the third work shift, experimental animals and time-matched undisturbed controls were euthanized (rest work at ZT12; active work at ZT0). Tissue lysates from two brain regions (prefrontal cortex, PFC and hippocampus) implicated in cognition and sleep loss, were analyzed with m7GTP (cap) pull-down to exa...Continue Reading

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Citations

Sep 10, 2020·International Journal of Molecular Sciences·Abdelnaby KhalyfaDavid Gozal
May 11, 2019·International Journal of Molecular Sciences·Ellen PaatelaNobuaki Kikyo
Oct 17, 2021·Nature Communications·Alessandra StangherlinJohn S O'Neill
Nov 4, 2021·Chronobiology International·Hans G RichterCarlos Spichiger

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