PMID: 11325448Apr 28, 2001Paper

No evidence for a different magnitude of the time factor for continuously fractionated irradiation and protocols including gaps in two human squamous cell carcinoma in nude mice

Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology
M BaumannD Zips

Abstract

To study whether the magnitude of the time factor is different for continuously fractionated irradiation and for fractionation protocols including gaps. Two human head and neck squamous cell carcinomas (SCCs), FaDu and GL, were transplanted subcutaneously into the right hindleg of NMRI (nu/nu) mice and irradiated with 30 fractions under ambient conditions within 2, 6 and 10 weeks. Irradiations within 6 and 10 weeks were given either as a continuous course or with a mid-course gap of 3 weeks. The end-point of the experiments was local tumor control at day 120 (FaDu) or day 180 (GL) after the end of treatment. In FaDu tumors, two experimental cohorts (A, B) yielded significantly different results and were analyzed separately. In cohort A, the tumor control dose 50% (TCD50) increased from 37 to 89 Gy when the treatment time of continuous fractionated irradiation was extended from 2 to 10 weeks. The recovered dose/day (D(r)) was 0.98 Gy (95% confidence interval, 0.72; 1.27). In cohort B, the TCD50 increased from 35 to 63 Gy, and the D(r) was 0.51 Gy (0.24; 0.75). In GL tumors, the TCD50 for continuously fractionated irradiation increased from 41 to 48 Gy. This increase was not significant, and the D(r) was 0.15 Gy (0; 0.30). None o...Continue Reading

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Citations

Sep 25, 2001·International Journal of Radiation Oncology, Biology, Physics·C PetersenM Baumann
Feb 28, 2003·International Journal of Radiation Oncology, Biology, Physics·Rafal TarnawskiKrzysztof Skladowski
Oct 20, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Edgar Ben-JosefChristopher Willett
Apr 2, 2013·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Rebecca Bütof, Michael Baumann
Jan 31, 2003·Clinical Oncology : a Journal of the Royal College of Radiologists·R G DaleJ A Sinclair

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