No evidence for a direct role of Helicobacter pylori and Mycoplasma pneumoniae in carotid artery atherosclerosis.

Journal of Clinical Pathology
T W WeissJ Wojta

Abstract

That infections with certain pathogens, by initiating an inflammatory response, may contribute to the development of atherosclerosis is suggested by clinical and experimental evidence. To analyse atherosclerotic plaques of the carotid artery, samples of apparently healthy greater saphenous veins and circulating leucocytes from the same individual patients for the presence of Helicobacter pylori and Mycoplasma pneumoniae. Samples from 36 patients undergoing carotid endarterectomy for symptomatic carotid artery stenosis were analysed by polymerase chain reaction for the presence of DNA specific for H. pylori and M. pneumoniae. IgG antibody titres against H. pylori and M pneumoniae and plasma levels of soluble E-selectin, soluble intercellular adhesion molecule-1 and soluble vascular cell adhesion molecule-1 were determined. M. pneumoniae-specific DNA was detected in the atherosclerotic plaques of 13 of 36 (36.1%) patients, in the saphenous veins of 9 of 36 (25%) patients and in the leucocytes of 27 of 36 (75%) patients. No salient association was observed between the presence of M. pneumoniae-specific DNA in leucocytes and atherosclerotic plaques or veins. A marked correlation between the presence of M. pneumoniae in the respecti...Continue Reading

References

May 1, 1986·American Journal of Diseases of Children·S C ChenS Nouri
Feb 11, 1988·Nucleic Acids Research·S A MillerH F Polesky
Aug 18, 1994·The New England Journal of Medicine·G LiuzzoA Maseri
Jan 1, 1997·Mayo Clinic Proceedings·R S FarrajT F Smith
May 3, 1997·BMJ : British Medical Journal·F ParenteG Bianchi Porro
Jul 1, 1997·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·C PerezR Guarch
May 26, 1998·Journal of the Neurological Sciences·M FuG W Wong
Jan 14, 1999·The New England Journal of Medicine·R Ross
Apr 8, 1999·Journal of Clinical Pathology·D Taylor-Robinson, B J Thomas
May 7, 1999·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·H AlakärppäA Laurila
Sep 6, 2000·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·M L HiguchiJ A Ramires
Feb 7, 2001·Stroke; a Journal of Cerebral Circulation·S F AmerisoG E Sevlever
Apr 3, 2001·Stroke; a Journal of Cerebral Circulation·R LaBicheT J DeGraba
Dec 12, 2001·Stroke; a Journal of Cerebral Circulation·S C JohnstonD Dean
Jan 22, 2002·Archives of Pathology & Laboratory Medicine·Larry J DobbsLori Earls
Jul 10, 2002·Circulation·Abhiram PrasadArshed A Quyyumi
Sep 10, 2002·Revista Do Instituto De Medicina Tropical De São Paulo·Maria de Lourdes HiguchiMaurício Wajngarten
May 10, 2003·FEMS Immunology and Medical Microbiology·Magdalena ChmielaWieslawa Rudnicka
Apr 20, 2005·Journal of the American College of Cardiology·Tetsuya OshimaMasayuki Kambe

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Citations

Feb 23, 2010·Circulation Journal : Official Journal of the Japanese Circulation Society·Bogdan JegierMalgorzata Lelonek
Oct 11, 2007·Helicobacter·Ulrich R M BohrAntonio Gasbarrini
Jul 29, 2008·American Journal of Physiology. Heart and Circulatory Physiology·Nicholas P TobinPhilip M Cummins
May 24, 2015·Current Opinion in Rheumatology·Alison Clifford, Gary S Hoffman

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