No evidence for amplification of 25-hydroxyvitamin D-1alpha-OHase (1alpha-OHase) or 1,25-dihydroxyvitamin D-24-OHase (24-OHase) genes in malignant melanoma (MM)

The Journal of Steroid Biochemistry and Molecular Biology
Jörg ReichrathMarkus Seifert

Abstract

Increasing evidence points at an important function of Vitamin D metabolites for growth regulation in various tissues, including MM. Using array CGH, amplification of 24-OHase was recently detected as a likely target oncogene of the amplification unit 20q13.2 in breast cancer cell lines and tumors. Additionally, amplification of 1alpha-OHase has been reported in human malignant glioma. Using immunohistochemistry, we have now detected nuclear Vitamin D receptor (VDR) immunoreactivity in primary cutaneous malignant melanoma (MM), indicating that Vitamin D metabolites may be of importance for the growth regulation in these tumors. Using Southern analysis, we have analyzed MM and metastases for evidence of amplification of 1alpha-OHase or 24-OHase genes. Our results do not support the hypothesis that amplification of 1alpha-OHase or 24-OHase genes may be of importance for pathogenesis or progression of MM.

References

May 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·A R BakerB W O'Malley
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Aug 14, 2002·The British Journal of Dermatology·J E Osborne, P E Hutchinson

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Citations

Sep 3, 2010·Dermato-endocrinology·Jörg Reichrath, Bernd Nürnberg
Oct 16, 2012·Journal of the American Academy of Dermatology·Jean Y TangMaryam M Asgari
Oct 11, 2017·American Journal of Clinical Dermatology·Elio Kechichian, Khaled Ezzedine
Mar 5, 2011·Molecular Oncology·Sinead Field, Julia A Newton-Bishop
Sep 29, 2010·Experimental Dermatology·Joel Pinczewski, Andrzej Slominski

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