No evidence for an effect of COMT Val158Met genotype on executive function in patients with 22q11 deletion syndrome

The American Journal of Psychiatry
Bronwyn GlaserStephan Eliez

Abstract

Previous studies linking the catechol O-methyltransferase (COMT) functional polymorphism to the specific phenotype in 22q11.2 deletion syndrome (22q11.2DS) have yielded inconsistent results. The goal of the present study was to replicate a recent finding that executive function is higher in individuals hemizygous for the Met allele. Thirty-four children and young adults with a 22q11.2 microdeletion, hemizygous for the Val (N=14) or Met (N=20) polymorphism, were tested on measures of executive function, IQ, and memory. No significant differences were detected between Met- and Val-hemizygous participants on measures of executive function. The groups did not differ on full-scale, performance, and verbal IQ or on verbal and visual memory. These results suggest either a small effect of the COMT polymorphism on executive function in 22q11.2DS or no effect at all. Further research is needed to characterize the implications of hemizygosity of COMT in 22q11.2DS for cognitive function.

Citations

May 17, 2011·Behavior Genetics·Nicole Philip, Anne Bassett
Sep 5, 2008·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Jacob A S VorstmanChantal Kemner
Jan 30, 2010·Journal of Mental Health Research in Intellectual Disabilities·Doron GothelfRobert J Shprintzen
Jan 5, 2011·Medicine·Donna M McDonald-McGinn, Kathleen E Sullivan
Feb 28, 2009·Cognitive, Affective & Behavioral Neuroscience·Yukari TakaraeTony J Simon
Sep 1, 2011·Behavioural Brain Research·Katherine H KarlsgodtDavid C Glahn
Jul 19, 2011·Research in Developmental Disabilities·Frederick FurnissNiraj Singh
Dec 23, 2009·Neuroscience and Biobehavioral Reviews·Dustin WahlstromMonica Luciana
Jun 22, 2007·Critical Care Medicine·Alan H Morris
Jun 4, 2008·Critical Care Medicine·Alan H MorrisHomer Warner
Apr 9, 2008·Biological Psychology·Carrie E BeardenPaul M Thompson
Apr 12, 2007·Human Brain Mapping·Doron GothelfAllan L Reiss
Jul 19, 2008·Developmental Disabilities Research Reviews·Kevin M AntshelWendy R Kates
Jul 19, 2008·Developmental Disabilities Research Reviews·Doron GothelfStephan Eliez
Feb 13, 2009·Developmental Disabilities Research Reviews·Bert De SmedtPol Ghesquière
Jun 15, 2007·Child and Adolescent Psychiatric Clinics of North America·Doron Gothelf
Sep 3, 2013·Biological Psychiatry·Rachel K JonasCarrie E Bearden
Jun 25, 2015·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Ece D GamsizEric M Morrow
May 22, 2010·Psychiatry Research·Vandana ShashiThomas R Kwapil
Sep 3, 2013·Biological Psychiatry·Doron GothelfDaniel R Weinberger
Oct 24, 2007·The International Journal of Neuropsychopharmacology·Elena MichaelovskyAbraham Weizman
Jun 25, 2014·Frontiers in Psychology·Heather M ShapiroTony J Simon
Sep 13, 2005·Neuropsychologia·Martin DebbanéStephan Eliez
Jun 22, 2006·Neuropsychologia·Martin DebbanéStephan Eliez
Sep 14, 2016·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Colleen P FranconiBeverly S Emanuel
Mar 24, 2010·The Australian and New Zealand Journal of Psychiatry·Linda E CampbellKieran C Murphy
Dec 14, 2007·Zeitschrift für Kinder- und Jugendpsychiatrie und Psychotherapie·Wolfgang Briegel
May 13, 2009·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Eliotte Hirshberg
Sep 18, 2007·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Alan H Morris
Sep 4, 2010·Journal of Developmental and Behavioral Pediatrics : JDBP·Elena L GrigorenkoEinar Mencl
Jul 19, 2008·Developmental Disabilities Research Reviews·Sarah E PrasadKieran C Murphy
May 31, 2017·Translational Psychiatry·S SanninoF Papaleo
Dec 1, 2006·Human Molecular Genetics·Grégory RauxDominique Campion
May 26, 2011·The Journal of Trauma·Bruce A McKinleyFrederick A Moore

❮ Previous
Next ❯

Methods Mentioned

BETA
genotyping

Related Concepts

Related Feeds

22q11 Deletion Syndrome

22q11.2 deletion syndrome, also known as DiGeorge syndrome, is a congenital disorder caused by a partial deletion of chromosome 22. Symptoms include heart defects, poor immune system function, a cleft palate, complications related to low levels of calcium in the blood, and delayed development. Discover the latest research on this disease here.