No evidence for association between APOL1 kidney disease risk alleles and Human African Trypanosomiasis in two Ugandan populations

PLoS Neglected Tropical Diseases
Magambo Phillip KimudaTrypanoGEN Research Group as members of The H3Africa Consortium

Abstract

Human African trypanosomiasis (HAT) manifests as an acute form caused by Trypanosoma brucei rhodesiense (Tbr) and a chronic form caused by Trypanosoma brucei gambiense (Tbg). Previous studies have suggested a host genetic role in infection outcomes, particularly for APOL1. We have undertaken candidate gene association studies (CGAS) in a Ugandan Tbr and a Tbg HAT endemic area, to determine whether polymorphisms in IL10, IL8, IL4, HLAG, TNFA, TNX4LB, IL6, IFNG, MIF, APOL1, HLAA, IL1B, IL4R, IL12B, IL12R, HP, HPR, and CFH have a role in HAT. We included 238 and 202 participants from the Busoga Tbr and Northwest Uganda Tbg endemic areas respectively. Single Nucleotide Polymorphism (SNP) genotype data were analysed in the CGAS. The study was powered to find odds ratios > 2 but association testing of the SNPs with HAT yielded no positive associations i.e. none significant after correction for multiple testing. However there was strong evidence for no association with Tbr HAT and APOL1 G2 of the size previously reported in the Kabermaido district of Uganda. A recent study in the Soroti and Kaberamaido focus in Central Uganda found that the APOL1 G2 allele was strongly associated with protection against Tbr HAT (odds ratio = 0.2, 95% ...Continue Reading

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Oct 28, 2017·PLoS Neglected Tropical Diseases·Elvis OfonUNKNOWN TrypanoGEN Research Group, as members of The H3Africa Consortium

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Citations

Dec 6, 2018·Current Opinion in Organ Transplantation·Fasika M Tedla, Ernie Yap
Aug 15, 2019·PLoS Neglected Tropical Diseases·Kelita KamotoUNKNOWN TrypanoGEN Research Group as members of The H3Africa Consortium
Mar 7, 2020·NPJ Genomic Medicine·Amy R BentleyCharles N Rotimi
Sep 24, 2020·AAS Open Research·Olivier Fataki AsinaUNKNOWN TrypanoGEN Group, as members of The H3Africa Consortium
Oct 30, 2020·Nature·Ananyo ChoudhuryNeil A Hanchard
Feb 14, 2021·NPJ Genomic Medicine·Amy R BentleyCharles N Rotimi
Jun 11, 2018·Trends in Molecular Medicine·Pazit Beckerman, Katalin Susztak

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Datasets Mentioned

BETA
EGAS00001002602

Methods Mentioned

BETA
genotyping
Assay
PCR

Software Mentioned

StructurePlot2
Plink
Assay Design Suite
R
Typer
Genetics Analysis Package gap
MassArray RT
Admixture

Related Concepts

Related Feeds

African Trypanosomiasis

African trypanosomiasis, also known as sleeping sickness, is an insect-borne parasitic disease of humans and other animals. It is caused by protozoa of the species Trypanosoma brucei and almost invariably progresses to death unless treated. Discover the latest research on African trypanosomiasis here.

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