PMID: 11604059Oct 18, 2001Paper

No evidence for chromosomal instability in radiation workers with in vivo exposure to plutonium

Radiation Research
Caroline A Whitehouse, E Janet Tawn

Abstract

The availability of cultured lymphocyte preparations from radiation workers with internal deposits of plutonium provided the opportunity to examine whether irradiation of bone marrow cells had induced a transmissible genomic instability manifesting as an increase in de novo chromosome aberrations in descendant cells in the peripheral blood. The men were originally classified as having more than 20% of the maximum permissible body burdens of plutonium, and recent red bone marrow dose calculations provided individual cumulative estimates at the time of sampling ranging up to 1.8 Sv. The initial sampling occurred approximately 10 years after the main major intake, and samples were subsequently taken during three further periods over the following 20 years. Control samples were available from three of the four sampling times. Chromosome analysis of solid Giemsa-stained material revealed no significant differences either in comparisons between the total group of plutonium workers and controls for comparable periods or when the comparisons were restricted to a group of plutonium workers with initial red bone marrow plutonium doses greater than 0.25 Sv. However, the frequencies of cells containing chromatid exchanges, chromatid breaks...Continue Reading

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Citations

Apr 10, 2014·Radiation and Environmental Biophysics·Natalia V SotnikTamara V Azizova
Apr 24, 2010·Radiation Protection Dosimetry·Lawrence T DauerPhung Tran
Mar 16, 2007·International Journal of Radiation Biology·A SeoaneF Dulout
Apr 1, 2010·International Journal of Radiation Biology·Volodymyr A VinnikovDavid Lloyd
Aug 4, 2010·International Journal of Radiation Biology·Ryuji OkazakiToshiyuki Norimura
Dec 25, 2012·Mutation Research·Munira KadhimMark P Little
Mar 27, 2010·Mutation Research·Sebastian ZahnreichClaudia Fournier
Sep 12, 2012·Scientific Reports·C FournierS Ritter
Nov 9, 2004·Mutation Research·Brian PonnaiyaCharles R Geard
Nov 9, 2004·Mutation Research·Philip J CoatesEric G Wright
Jul 1, 2004·Mutation Research·Catherine SauvagetCharles A Waldren
Jan 28, 2006·Mutation Research·Eric G Wright, Philip J Coates
Jan 1, 2012·Dose-response : a Publication of International Hormesis Society·A BelchiorP Vaz
Jul 11, 2003·Health Physics·John D BoiceMarilyn Stovall
Mar 31, 2005·Journal of Radiological Protection : Official Journal of the Society for Radiological Protection·E Janet Tawn, Caroline A Whitehouse
Nov 29, 2016·Journal of Radiological Protection : Official Journal of the Society for Radiological Protection·K H Chadwick

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