No evidence for deletions of the NBS1 gene in lymphomas

Cancer Genetics and Cytogenetics
M StummB Schlegelberger

Abstract

Patients with Nijmegen breakage syndrome (NBS) have a high risk to develop malignant diseases, most frequently B-cell lymphomas. The NBS gene product, nibrin, is involved in DNA recombination repair, a function shared with known tumor suppressor genes like BRCA1 and BRCA2. This led us to investigate whether NBS acts as tumor suppressor gene in the development of non-Hodgkin lymphomas. Therefore, we performed fluorescence in situ hybridization analysis using a BAC clone containing the entire NBS1 region on eight B-cell and eight T-cell lymphomas, including one B-cell and two T-cell lymphomas with structural abnormalities of 8q. None of the tumors showed a deletion of the NBS1 gene, demonstrating that deletion of the NBS1 gene is not a major cause or a primary event in tumorigenesis of human B- and T-cell lymphomas.

Citations

Nov 13, 2002·Mutation Research·Larry H Thompson, David Schild
Jan 1, 2003·Genes, Chromosomes & Cancer·Alessandra TessitoreStefano Martinotti
Apr 24, 2003·European Journal of Human Genetics : EJHG·Caterina TanzanellaPaola Maraschio
Sep 28, 2002·Genes, Chromosomes & Cancer·Karen M CerosalettiPatrick Concannon
Jul 1, 2005·Journal of Radiation Research·Sandrine H LefèvreBernard Malfoy
Jul 25, 2009·Journal of Neuro-oncology·Dorota Piekutowska-AbramczukKrystyna H Chrzanowska
Jul 23, 2005·The Journal of Biological Chemistry·Yen-Chung ChenKou-Juey Wu

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