PMID: 2864971Oct 1, 1985Paper

No evidence for differences between pre- and post-junctional alpha 2-adrenoceptors

British Journal of Pharmacology
J R Docherty, L Hyland

Abstract

We have examined the pre- and post-junctional effects of a series of alpha-adrenoceptor agonists and antagonists at alpha 2-adrenoceptors in the pithed rat preparation and the human isolated saphenous vein. In the pithed rat, there was no difference in relative agonist and antagonist potencies between pre- and post-junctional alpha 2-adrenoceptors but the absolute potencies of antagonists differed: antagonists were more potent prejunctionally. In the human saphenous vein, the alpha 2-adrenoceptor antagonist yohimbine had pre- and post-junctional actions over the same concentration range. We have no evidence to suggest differences between pre- and post-junctional alpha 2-adrenoceptors: differences in absolute antagonist potencies in the pithed rat may be due to non-equilibrium conditions.

References

Jul 13, 1984·European Journal of Pharmacology·M GöthertH R Zerkowski
Sep 5, 1980·European Journal of Pharmacology·J W ConstantineR A Weeks

❮ Previous
Next ❯

Citations

Oct 1, 1987·Naunyn-Schmiedeberg's Archives of Pharmacology·R R RuffoloJ P Hieble
Aug 1, 1995·British Journal of Pharmacology·M O'RourkeJ R Docherty
Jan 1, 1994·British Journal of Pharmacology·L C Rump, I von Kügelgen
Dec 1, 1989·Journal of Autonomic Pharmacology·M L CuffíA Badia
Oct 1, 1989·Medicinal Research Reviews·J C McGrathV G Wilson

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adrenergic Receptors: Trafficking

Adrenergic receptor trafficking is an active physiological process where adrenergic receptors are relocated from one region of the cell to another or from one type of cell to another. Discover the latest research on adrenergic receptor trafficking here.