No evidence for human papillomavirus having a causal role in salivary gland tumors

Diagnostic Pathology
Linnea HaeggblomAnders Näsman

Abstract

Salivary gland malignancies are a very heterogeneous group of cancers, with histologically > 20 different subtypes, and prognosis varies greatly. Their etiology is unknown, however, a few small studies show presence of human papillomavirus (HPV) in some subtypes, although the evidence for HPV having a causal role is weak. The aim of this study was to investigate if HPV plays a causal role in the development of different parotid salivary gland tumor subtypes. DNA was extracted from 107 parotid salivary gland formalin fixed paraffin embedded tumors and 10 corresponding metastases, and tested for 27 different HPV types using a multiplex bead based assay. HPV DNA positive tumors were stained for p16INK4a overexpression by immunohistochemistry. One of the 107 malignant parotid salivary gland tumors (0.93%) and its corresponding metastasis on the neck were positive for HPV16 DNA, and both also overexpressed p16INK4a. The HPV positive primary tumor was a squamous cell carcinoma; neither mucoepidermoid nor adenoid cystic tumors were found HPV positive. In conclusion, HPV DNA analysis in a large number of malignant parotid salivary gland tumors, including 12 different subtypes, did not show any strong indications that tested HPV types h...Continue Reading

References

May 4, 2000·Journal of the National Cancer Institute·M L GillisonD Sidransky
Mar 31, 2005·Advances in Cancer Research·Hanna Mellin Dahlstrand, Tina Dalianis
Dec 14, 2011·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Jennifer M BolandDavid J Schembri-Wismayer
Jan 5, 2012·Current Treatment Options in Oncology·M Boyd GillespieDavid W Eisele
Jul 13, 2012·Head and Neck Pathology·Tatyana IsayevaMargaret Brandwein-Gensler
Aug 31, 2012·Emerging Infectious Diseases·Juan DuTina Dalianis
Aug 21, 2013·Scandinavian Journal of Infectious Diseases·Cecilia NordforsTina Dalianis
Aug 20, 2014·The Journal of International Medical Research·Frank Cheau-Feng LinStella Chin-Shaw Tsai
Jun 10, 2016·International Journal of Oncology·Xu QianAndreas E Albers

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Citations

Jul 7, 2019·BMC Veterinary Research·Elizabeth A F SchaeferBrian K Flesner
May 29, 2020·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Erik A WilliamsMark C Mochel
Sep 24, 2020·International Journal of Molecular Sciences·Ha Young ChoSo Hee Kwon
Sep 7, 2020·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Erik A WilliamsMark C Mochel

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Methods Mentioned

BETA
PCR

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