No evidence for increased mortality in SDHD variant carriers compared with the general population

European Journal of Human Genetics : EJHG
L T van HulsteijnO M Dekkers

Abstract

Germline variants in subunit D of the succinate dehydrogenase gene (SDHD variants) are associated with an increased risk of developing paragangliomas. The aim of this study was to compare mortality rates and survival in a Dutch cohort of SDHD variant carriers with those in the general population. The study was conducted at the Leiden University Medical Center, a tertiary referral center for patients with paragangliomas. Included subjects all tested positive for SDHD variants before 1 July 2012 and visited the departments of Otorhinolaryngology or Endocrinology at least once or had a diagnosed paraganglioma and a SDHD variant-positive family history. Clinical data were retrieved from medical records, information on mortality was obtained from the Municipal Personal Records Database, and mortality rates for the Dutch population were obtained from the Dutch Central Bureau of Statistics, stratified by sex, age and date. SDHD variant carriers were followed from the date of first SDHD variant-related contact until death, emigration or 12 December 2012 and the standardized mortality ratio (SMR) was calculated. Two-hundred and seventy-five SDHD variant carriers were included in the study, of which 80% carried the c.274G>T, p.(Asp92Tyr)...Continue Reading

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May 12, 2016·Journal of Internal Medicine·P BjörklundJ Crona
May 20, 2018·European Journal of Human Genetics : EJHG·Berdine L HeestermanJeroen C Jansen
Jan 20, 2019·Cancers·Johannes A RijkenErik F Hensen

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