PMID: 8950017Nov 1, 1996Paper

No evidence for involvement of angiotensin II in spatial learning in water maze in rats

Behavioural Brain Research
A Chalas, E L Conway

Abstract

There is increasing evidence suggesting angiotensin II (AII) may inhibit memory formation in a range of conditioned avoidance and habituation learning tasks in rodents. We were interested to determine if AII might also play an inhibitory role in spatial learning. Angiotensin-converting enzyme (ACE) inhibitors, which block the formation of AII from AI, improve acquisition and/or retention of basal performance inhibited by the muscarinic receptor antagonist, scopolamine, in conditioned avoidance and habituation tasks. In hooded Wistar rats, over 5 days of training in a water maze neither the ACE inhibitor, ceranapril 5 and 50 micrograms/kg/day, nor the ACE inhibitor, ramipril 2 and 10 mg/kg/day, altered the increase in path length produced by administration of scopolamine 0.75 mg/kg/day. In probe trails (without platform), on the last day of training, ceranapril 50 micrograms/kg produced a 35% further deterioration in performance in the scopolamine-treated rats (P < 0.02). Administration of the substrate, renin, that leads to AII formation, did not alter water maze performance over 5 days of training. The angiotensin receptor antagonist, losartan, has been shown to improve basal and scopolamine-impaired performance in a habituati...Continue Reading

References

Dec 20, 1991·Brain Research·J B DennyD L Armstrong
Mar 1, 1991·Pharmacology, Biochemistry, and Behavior·R K McNamara, R W Skelton
Jan 1, 1990·Psychopharmacology·C Mondadori, P Etienne
Jul 1, 1989·Pharmacology, Biochemistry, and Behavior·B CostallD M Tomkins
Mar 1, 1984·Brain Research·T J Teyler, P Discenna
Aug 24, 1993·European Journal of Pharmacology·J F Flood, J E Morley
Jun 1, 1993·Pharmacology, Biochemistry, and Behavior·M J WaynerJ B Denny

❮ Previous
Next ❯

Citations

Nov 20, 2004·Psychopharmacology·Daniel S KerrMartín Cammarota
Nov 10, 1995·Regulatory Peptides·J W Wright, J W Harding
Apr 12, 2003·Clinical and Experimental Pharmacology & Physiology·Maarten van den Buuse
May 16, 2006·Hormones and Behavior·Juliana S BoniniMartín Cammarota
Dec 26, 2012·Progress in Neuro-psychopharmacology & Biological Psychiatry·Walther BildAlin Ciobica
May 21, 2019·American Journal of Alzheimer's Disease and Other Dementias·Daniela Carmen AbabeiWalther Bild

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.