No evidence for linkage of chromosome 22 markers to schizophrenia in southern African Bantu-speaking families

American Journal of Medical Genetics
B P RileyR Williamson

Abstract

Previous studies have demonstrated possible linkage between chromosome 22 and one of the hypothesized schizophrenia susceptibility genes. Interpretation of these data, however, is not straightforward: although not significant at the level traditionally accepted to demonstrate linkage, reported lod scores were greater than should have occurred by chance for an unlinked marker based on simulation studies. Further, these studies used sample populations which were either of mixed nationality and ethnicity, or mixed ethnic ancestry from one country. We therefore tested for linkage between highly polymorphic chromosome 22 markers and schizophrenia in a sample of southern African Bantu-speaking black families, a population known to have diverged within the last 2,000 years. We also tested one candidate locus, the gene for the soluble form of catechol-O-methyl transferase (COMT) located at 22q11, which has been suggested as the cause of psychiatric symptoms observed in velo-cardio-facial syndrome (VCFS, including DiGeorge syndrome), and which is known to be functionally as well as genetically polymorphic. There is no evidence to support the linkage of markers on chromosome 22 to susceptibility to schizophrenia in this population, using...Continue Reading

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Citations

Mar 10, 2004·Molecular Psychiatry·B J MowryD F Levinson
Sep 10, 2005·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·S V FaraoneG D Schellenberg
Mar 19, 2014·Frontiers in Behavioral Neuroscience·Sean C Godar, Marco Bortolato
May 19, 2005·Psychiatric Genetics·Herbert M LachmanTakuya Saito
Jan 1, 2013·The African Archaeological Review·J M MwacharoO Hanotte
May 17, 2000·American Journal of Medical Genetics·B P Riley, P McGuffin

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22q11 Deletion Syndrome

22q11.2 deletion syndrome, also known as DiGeorge syndrome, is a congenital disorder caused by a partial deletion of chromosome 22. Symptoms include heart defects, poor immune system function, a cleft palate, complications related to low levels of calcium in the blood, and delayed development. Discover the latest research on this disease here.