No evidence for preferential involvement of medial temporal lobe structures in high-functioning autism

Psychological Medicine
Saskia J M C PalmenHerman Van Engeland

Abstract

Autism is a neurodevelopmental disorder associated with slight increases in brain volume. There has been some suggestion that medial temporal lobe structures may be preferentially involved in this disorder, although results have not always been consistent. Here, we investigate amygdala and hippocampus volumes in medication-naive subjects with high-functioning autism. Whole-brain magnetic resonance imaging scans were acquired from 42 patients and 42 closely matched, healthy control subjects. Amygdala volume did not differ significantly between patients and controls. A significant increase in hippocampal volume was proportional to an increase in overall brain volume. These results argue against preferential involvement of medial temporal lobe structures in autism, at least in high-functioning medication-naive individuals.

Citations

Nov 9, 2007·Journal of Autism and Developmental Disorders·Ben CordenDavid Skuse
Jul 15, 2009·Biological Psychiatry·Hein J F van MarleGuillén Fernández
Oct 29, 2008·Journal of the International Neuropsychological Society : JINS·Thomas E ConturoNancy J Minshew
Jul 3, 2013·Epidemiology and Psychiatric Sciences·M BellaniP Brambilla
Apr 19, 2013·Social Cognitive and Affective Neuroscience·Nim TottenhamB J Casey
Mar 11, 2010·Behavioral and Brain Functions : BBF·Luigi Mazzone, Paolo Curatolo
Jul 4, 2008·European Journal of Pediatrics·Jean G Steyaert, Wouter De la Marche
Jun 10, 2011·Cognitive, Affective & Behavioral Neuroscience·Marjorie SolomonCameron S Carter
Nov 7, 2007·Neuroimaging Clinics of North America·Diane L Williams, Nancy J Minshew
Jan 21, 2014·Journal of Child Psychology and Psychiatry, and Allied Disciplines·Guillermo HorgaBradley S Peterson
Sep 29, 2011·Autism Research : Official Journal of the International Society for Autism Research·Clodagh M MurphyD G Murphy
Jan 17, 2007·Biological Psychiatry·Marieke LangenHerman van Engeland
May 25, 2010·Journal of the American Academy of Child and Adolescent Psychiatry·Wouter GroenIndira Tendolkar
Jun 2, 2015·Frontiers in Human Neuroscience·Farah Focquaert, Sven Vanneste
Mar 24, 2016·Clinical Anatomy : Official Journal of the American Association of Clinical Anatomists & the British Association of Clinical Anatomists·Fareed JumahR Shane Tubbs
Oct 1, 2013·Progress in Neuro-psychopharmacology & Biological Psychiatry·Naama Barnea-GoralyAntonio Y Hardan
Sep 16, 2016·Frontiers in Neuroscience·Alessandro GrecucciRemo Job
Feb 15, 2012·Autism : the International Journal of Research and Practice·Jill Boucher, Andrew Mayes
Sep 16, 2016·Journal of Child Neurology·Alison S CooperCynthia Mollen
Sep 21, 2013·Journal of Autism and Developmental Disorders·Calixto MachadoCarlos Beltrán
Aug 17, 2018·Clinical Anatomy : Official Journal of the American Association of Clinical Anatomists & the British Association of Clinical Anatomists·S LucibelloR Battini
Nov 15, 2006·Annals of the New York Academy of Sciences·E KorpershoekW N M Dinjens
Mar 12, 2008·Brain : a Journal of Neurology·Imke A J van KootenChristoph Schmitz
Feb 28, 2007·Mental Retardation and Developmental Disabilities Research Reviews·Ralph-Axel Müller
Apr 13, 2011·Journal of Neurodevelopmental Disorders·Noah J SassonAysenil Belger
Aug 20, 2017·BMC Neuroscience·Ahmad ChaddadCamel Tanougast
Dec 22, 2017·Human Brain Mapping·Clare R GibbardChris A Clark
Nov 29, 2020·The Journal of Comparative Neurology·José-Carlos Delgado-GonzálezEmilio Artacho-Pérula

❮ Previous
Next ❯

Related Concepts

Related Feeds

Amygdala and Midbrain Dopamine

The midbrain dopamine system is widely studied for its involvement in emotional and motivational behavior. Some of these neurons receive information from the amygdala and project throughout the cortex. When the circuit and transmission of dopamine is disrupted symptoms may present. Here is the latest research on the amygdala and midbrain dopamine.

Autism

Autism spectrum disorder is associated with challenges with social skills, repetitive behaviors, and often accompanied by sensory sensitivities and medical issues. Here is the latest research on autism.

Amygdala: Sensory Processes

Amygdalae, nuclei clusters located in the temporal lobe of the brain, play a role in memory, emotional responses, and decision-making. Here is the latest research on sensory processes in the amygdala.