No evidence for selective GABAergic interneuron deficits in the anterior thalamic complex of patients with schizophrenia

Progress in Neuro-psychopharmacology & Biological Psychiatry
Gavin Dixon, Clive G Harper

Abstract

Fewer neurons have been reported in the anterior thalamic complex (AT) of individuals diagnosed with schizophrenia in comparison to control tissue. In addition, the density of presumptive thalamo-cortical relay neurons of the AT is reported to be significantly decreased in schizophrenia compared with controls whilst total AT neuron density appears unchanged. We have investigated whether schizophrenia alters either the density of presumptive interneurons or the ratio between the two fundamental neuron types within the AT by immunohistochemically visualizing GABAergic neurons in post-mortem brain tissue from individuals with a diagnosis of schizophrenia pair-matched to tissue from normal individuals. Qualitative observations indicated no obvious differences between the two cohorts in the morphology of neurons exhibiting a GABAergic phenotype. A cell counting analysis of AT neurons revealed: (1) a non-significant 1% increase in density of GABAergic neurons in schizophrenia compared with controls and (2), a non-significant 6% increase in the percentage of neurons with a GABAergic phenotype in the schizophrenia group compared with controls. These findings suggest that a reduction of AT neuron number in schizophrenia does not alter e...Continue Reading

References

Jul 1, 1991·Archives of General Psychiatry·A J SaykinP Stafiniak
Jan 1, 1994·Journal of Neuroscience Methods·A J HardingK Cullen
Apr 11, 1997·Schizophrenia Research·C L Beasley, G P Reynolds
Jun 23, 1999·Progress in Neuro-psychopharmacology & Biological Psychiatry·S IritaniH Kazamatsuri
Jun 26, 1999·The European Journal of Neuroscience·R MorrisD N Pandya
Dec 28, 1999·Brain : a Journal of Neurology·A HardingJ Kril
Jun 6, 2000·Biological Psychiatry·K A YoungD C German
Jul 26, 2000·Proceedings of the National Academy of Sciences of the United States of America·G J PopkenE G Jones
Apr 17, 2001·The Behavioral and Brain Sciences·J P Aggleton, M W Brown
Jan 5, 2002·The American Journal of Psychiatry·William ByneLiesl Jones
Apr 23, 2002·The Journal of Comparative Neurology·R W Guillery
Apr 6, 2004·The Journal of Comparative Neurology·Karl-Anton Dorph-PetersenDavid A Lewis

❮ Previous
Next ❯

Citations

Jul 8, 2008·Acta Neuropathologica·William ByneEileen Kemether
Aug 4, 2010·Biological Psychiatry·Karl-Anton Dorph-Petersen, David A Lewis
Aug 28, 2016·Schizophrenia Research·Karl-Anton Dorph-Petersen, David A Lewis
Apr 28, 2007·The Australian and New Zealand Journal of Psychiatry·Daren M DraganicVaughan J Carr
Dec 9, 2017·The Journal of Comparative Neurology·Xi Hua WuHenry John Waldvogel

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antipsychotic Drugs

Antipsychotic drugs are a class of medication primarily used to manage psychosis (including delusions, hallucinations, paranoia or disordered thought), principally in schizophrenia and bipolar disorder. Discover the latest research on antipsychotic drugs here