No evidence of a causal association of type 2 diabetes and glucose metabolism with atrial fibrillation.

Diabetologia
Hadi HaratiJoshua W Knowles

Abstract

Several epidemiological studies have shown an increased risk of atrial fibrillation in individuals with type 2 diabetes or milder forms of dysglycaemia. We aimed to assess whether this relation is causal using a Mendelian randomisation approach. Two-sample Mendelian randomisation was used to obtain estimates of the influence of type 2 diabetes, fasting blood glucose (FBG), and HbA1c on the risk of atrial fibrillation. Instrumental variables were constructed using available summary statistics from meta-analyses of genome-wide association studies (GWAS) for type 2 diabetes and associated phenotypes. Pleiotropic SNPs were excluded from the analyses. The most recent GWAS meta-analysis summary statistics for atrial fibrillation, which included over 1 million individuals (approximately 60,000 individuals with atrial fibrillation) was used for outcome analysis. Neither type 2 diabetes (OR 1.01 [95% CI 0.98, 1.03]; p = 0.37), nor FBG (OR 0.95 [95% CI 0.82, 1.09] per mmol/l; p = 0.49) or HbA1c (OR 1.01 [95% CI, 0.85, 1.17] per mmol/mol [%]; p = 0.88) were associated with atrial fibrillation in Mendelian randomisation analyses. We had >80% statistical power to detect ORs of 1.08, 1.06 and 1.09 or larger for type 2 diabetes, FBG and HbA1c...Continue Reading

References

May 3, 2011·The American Journal of Cardiology·Rachel R HuxleyAlvaro Alonso
Dec 10, 2016·Journal of the American College of Cardiology·Shabbar JamalyKristjan Karason
Jun 2, 2017·Diabetes·Robert A ScottUNKNOWN DIAbetes Genetics Replication And Meta-analysis (DIAGRAM) Consortium
Jul 2, 2017·Neurology·Susanna C LarssonUNKNOWN METASTROKE Collaboration and NINDS Stroke Genetics Network (SiGN)
Aug 1, 2018·Nature Genetics·Jonas B NielsenCristen J Willer

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