No evidence of adverse pregnancy outcome after exposure to ibuprofen in the first trimester - Evaluation of the national Embryotox cohort

Reproductive Toxicology
Katarina DatheC Schaefer

Abstract

Ibuprofen is an analgesic frequently used in the 1st and 2nd trimester of pregnancy. Most relevant studies deal with NSAID as a group and do not specifically focus on ibuprofen. In this study, 1117 women exposed to ibuprofen in the 1st trimester were compared to 2229 non-exposed women. Data were retrieved from the German Embryotox database. No significantly increased risk of major birth defects (4.8% vs. 4.1%; OR adjusted 1.11, 95% CI 0.75-1.64) or a distinct pattern of birth defects were found. The cumulative incidences of spontaneous abortions were similar across cohorts (15.5% vs. 16.6%; HR adjusted 0.85; 95% CI, 0.65-1.11). Subgroup analyses of pregnancies exposed for ≥7 (n = 223) and ≥30 days (n = 72) did not reveal a higher risk with increasing treatment duration. Ibuprofen does not seem to carry a substantial embryotoxic risk regarding the investigated endpoints.

Citations

Mar 7, 2019·Current Rheumatology Reports·Nicole Hunt, Mehret Birru Talabi
Mar 25, 2020·Current Opinion in Rheumatology·Mehret Birru Talabi, Megan E B Clowse
Oct 7, 2018·Current Pain and Headache Reports·Simy K Parikh
Jan 14, 2021·Cephalalgia : an International Journal of Headache·Roberta NosedaAlessandro Ceschi
Aug 21, 2021·Drug and Therapeutics Bulletin·Caroline Ovadia
Nov 23, 2021·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Sakita MoungmaithongLiona C Poon

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