PMID: 11920860Mar 29, 2002Paper

No evidence of an association between a functional monoamine oxidase a gene polymorphism and completed suicides

American Journal of Medical Genetics
H OnoK Maeda

Abstract

Monoamine oxidase A (MAOA) has been implicated in the control of aggression and/or impulsivity in humans and been involved in suicide. This gene has a functional polymorphism in which there is a variable number tandem repeat (VNTR) in the upstream region (MAOA-uVNTR). We hypothesized that MAOA dysfunction due to this polymorphism was associated with suicide genetically through the disinhibition of aggression and/or impulsivity. We performed an association study between completed suicides and the MAOA-uVNTR polymorphism. No significant difference in genotype distribution or allele frequencies was found between completed suicides and comparison groups either in males or females. These results show no evidence of an association between the MAOA-uVNTR polymorphism and completed suicides and suggest that MAOA is not involved in the susceptibility to suicide.

References

Jul 1, 1977·Acta Psychiatrica Scandinavica·M S BuchsbaumD L Murphy
Nov 1, 1975·Journal of Neurochemistry·C G GottfriesB Winblad
Jan 1, 1991·European Archives of Psychiatry and Clinical Neuroscience·F SherifL Oreland
Jan 1, 1986·Annals of the New York Academy of Sciences·H Y Meltzer, R C Arora
Jun 9, 1998·Annals of the New York Academy of Sciences·M Asberg
Nov 3, 1998·Human Genetics·S Z SabolD Hamer

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Citations

Apr 26, 2008·European Archives of Psychiatry and Clinical Neuroscience·San-Yuan HuangRu-Band Lu
Feb 8, 2006·Molecular Psychiatry·B BondyP Zill
May 5, 2005·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Christian P JacobKlaus Peter Lesch
May 18, 2005·Psychiatry and Clinical Neurosciences·Kenji OkamuraKiyoshi Maeda
Dec 21, 2006·Archives of Suicide Research : Official Journal of the International Academy for Suicide Research·Dan RujescuIna Giegling
Oct 28, 2010·Progress in Neuro-psychopharmacology & Biological Psychiatry·Shih-Jen TsaiYing-Jay Liou
Apr 29, 2008·The Psychiatric Clinics of North America·Jelena BrezoGustavo Turecki
Apr 29, 2008·The Psychiatric Clinics of North America·Dianne Currier, J John Mann
Sep 3, 2011·Developmental Science·Minghao ZhangZuhong Lu
Jan 22, 2013·Neuroscience·M BortolatoG Di Giovanni
Jan 15, 2013·Journal of Affective Disorders·Henriette N ButtenschønOle Mors
Nov 2, 2011·Journal of Affective Disorders·Chi-Fa HungPao-Yen Lin
May 20, 2004·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Yung-Yu HuangJ John Mann
Jan 16, 2007·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Fabrice JollantPhilippe Courtet
Aug 12, 2005·Psychiatric Genetics·Philippe CourtetAlain Malafosse
Apr 10, 2007·Psychiatric Genetics·Xingqun NiJames L Kennedy
Jun 26, 2003·Annals of Medicine·Daniel SoueryJulien Mendlewicz

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