No evidence of association of xenotropic murine leukemia virus-related virus with oral cancers: Experience from a tertiary care center in South India

Indian Journal of Cancer
M SinhaR S Jayshree

Abstract

Development of oral cancer, a widely prevalent cancer in India, is multifactorial with increased risk in those habituated to smoking, consuming alcohol and chewing paan and tobacco. This does not preclude other etiological factors in the causation of this cancer. Exploratory studies on several oncogenic viruses have found varied associations with oral cancers. The aim of this study was to explore the association of xenotropic murine leukemia virus-related virus, (XMRV) a retrovirus recently implicated in oncogenesis in humans, with oral cancers. The presence of XMRV proviral deoxyribonucleic acid (DNA) was evaluated by standard nucleic acid amplification from DNA extracted from representative bits of tumor tissues and adjacent normal tissues from surgically resected specimens sent post-operatively for routine histopathological testing. This prospective study comprised 109 patients with a provisional diagnosis of oral cancer who were operated at the Oral Oncology Department of Kidwai Memorial Institute of Oncology, over a period of 10 months. XMRV was not found in any of the tumor tissues (squamous cell carcinomas - 98; verrucous carcinomas - 4) nor in any of the normal tissues. It is thus important that the absence of this onco...Continue Reading

References

Dec 5, 2003·Journal of the National Cancer Institute·Rolando HerreroUNKNOWN IARC Multicenter Oral Cancer Study Group
Jan 20, 2007·Proceedings of the National Academy of Sciences of the United States of America·Beihua DongRobert H Silverman
Jul 3, 2008·American Journal of Reproductive Immunology : AJRI·Sreenivas AdurthiRudrapatna Subramanyam Jayshree
Jun 23, 2009·Journal of Cancer Research and Therapeutics·Noureen M Chocolatewala, Pankaj Chaturvedi
Oct 7, 2009·Proceedings of the National Academy of Sciences of the United States of America·Robert SchlabergIla R Singh
Mar 17, 2010·Head & Neck Oncology·Jerry MachadoSuzanne Kamel-Reid
May 29, 2010·Emerging Infectious Diseases·Nicole FischerMartin Aepfelbacher
Aug 19, 2010·Immunologic Research·Alice Rusmevichientong, Samson A Chow
Dec 2, 2010·Retrovirology·Christine A Kozak
Feb 26, 2011·International Journal of Cancer. Journal International Du Cancer·Jacques FerlayDonald Maxwell Parkin

❮ Previous
Next ❯

Related Concepts

Related Feeds

Carcinoma, Squamous Cell

Basal cell carcinoma is a form of malignant skin cancer found on the head and neck regions and has low rates of metastasis. Discover the latest research on basal cell carcinoma here.

Related Papers

The National Medical Journal of India
R V KumarM Vijayakumar
Journal of the College of Physicians and Surgeons--Pakistan : JCPSP
Faraz Ahmed BaigSaeed Khan
© 2021 Meta ULC. All rights reserved