No evidence of increased risk of thyroid dysfunction in well treated people living with HIV

AIDS
Mads HarsløfSusanne D Nielsen

Abstract

Possible effects of HIV on thyroid function in the modern combination antiretroviral therapy (cART) era are largely unknown. We aimed to investigate the prevalence and associated risk factors of thyroid dysfunction in well treated people living with HIV (PLWH) and matched uninfected controls and to examine whether HIV is independently associated with thyroid dysfunction. Thyroid-stimulating hormone (TSH), free thyroxine, total thyroxine, and free triiodothyronine were measured in 826 PLWH from the Copenhagen co-morbidity in HIV infection (COCOMO) Study and in 2503 matched uninfected controls, and medical treatment for hypothyroidism or hyperthyroidism was recorded. Multinomial logistic regression adjusting for known risk factor was used to examine the association between HIV and thyroid dysfunction and multivariate linear regression to study the association between HIV and serum TSH concentrations. The PLWH were generally well treated, with 95% having undetectable viral replication. Among PLWH and controls 31 (3.8%) and 114 (4.6%) had hypothyroidism, and 7 (0.8%) and 21 (0.8%) had hyperthyroidism, respectively. In adjusted analyses, we found no significant associations between HIV and hypothyroidism OR 0.8 [95% confidence inter...Continue Reading

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Citations

Dec 21, 2019·Scientific Reports·Martina ProperziEugenia Quiros-Roldan
Jan 23, 2020·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Vitvala JariyawattanaratChutintorn Sriphrapradang
Nov 27, 2020·Southern African Journal of HIV Medicine·Somasundram PillayRomashan Pillay
Jan 9, 2021·Frontiers in Endocrinology·Salvatore Benvenga

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