PMID: 9182822Jun 1, 1997Paper

No evidence of KSHV/HHV-8 in mycosis fungoides or associated disorders

The Journal of Investigative Dermatology
W B HengholdG S Wood

Abstract

The recently discovered human virus known as Kaposi's sarcoma-associated herpesvirus (KSHV) or human herpesvirus-8 (HHV-8) has been associated with body-cavity-based lymphomas in AIDS patients. It is most closely related to two other herpesviruses, the Epstein-Barr virus and herpesvirus saimiri, which are known to be associated with lymphomas in humans and nonhuman primates, respectively. To determine whether KSHV/HHV-8 is involved in the pathogenesis of mycosis fungoides (MF) and related disorders, we used a genomic PCR assay followed by confirmatory Southern blot analysis with a nested oligonucleotide probe to analyze cases for the presence of this virus. The specimens studied included fresh-frozen lesional tissues obtained from 16 patients with MF, seven with lymphomatoid papulosis, seven with primary cutaneous CD30+ large cell lymphoma of T-cell lineage, and five with Hodgkin's disease. Two T-cell tumor lines were also studied: MT4 (derived from a patient with adult T-cell leukemia/lymphoma) and Jurkat (derived from a patient with T-cell acute lymphoblastic leukemia). All cases were uniformly negative for KSHV/HHV-8, whereas Kaposi's sarcoma-positive controls and human beta-globin DNA integrity controls were appropriately p...Continue Reading

Citations

Mar 10, 2001·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·M KremerF Fend
Jun 9, 2005·Critical Reviews in Clinical Laboratory Sciences·Adina CohenRonit Sarid
Sep 23, 2008·Experimental Dermatology·Gaëlle QuéreuxBrigitte Dréno
Oct 19, 1999·The American Journal of Surgical Pathology·M Beylot-BarryJ P Merlio
Jun 10, 2003·Microbiology and Molecular Biology Reviews : MMBR·Lyubomir A DourmishevDavid M Lukac
May 20, 2004·British Journal of Cancer·S de SanjoséD Whitby
Jan 12, 2007·International Journal of Dermatology·Patsy LenaneS O'Loughlin

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