Abstract
Whether the myocardium in nonischemic heart failure experiences oxygen limitation remains a long-standing controversy. We addressed this question in patients with dilated cardiomyopathy (DCM) using a dual approach. First, we tested the changes in myocardial oxygenation between rest and stress states, using oxygenation-sensitive cardiovascular magnetic resonance. Second, we sought to assess the functional consequences of oxygen limitation at rest by measuring myocardial energetics before and after short-term oxygen supplementation. Twenty-six subjects (14 DCM and 12 normal) underwent cardiac magnetic resonance imaging at 3 Tesla to assess cardiac volumes, function, oxygenation, and first-pass perfusion (0.03 mmol/kg Gd-DTPA bolus) at stress and rest (4-6 minutes IV adenosine, 140 μg/kg per minute). Signal intensity change (SIΔ) and myocardial perfusion reserve index (MPRI) were measured from oxygenation and perfusion images, respectively. Furthermore, the effect of oxygen supplementation on resting myocardial energy metabolism was tested using (31)P MR spectroscopy, measuring PCr/ATP ratios in both groups at baseline and after 4 hours of oxygen via facemask in the DCM group. During stress, there were equivalent rises in rate pre...Continue Reading
References
Jun 1, 1983·The American Journal of Cardiology·D OpherkW Kübler
Jun 7, 1995·Molecular and Cellular Biochemistry·H N SabbahS Goldstein
Jul 1, 1994·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·P A Bottomley, R Ouwerkerk
Apr 27, 2001·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·R Pohmann, M von Kienlin
May 4, 2001·Computers in Biology and Medicine·A NaressiD Graveron-Demilly
Jun 8, 2001·Magma·A NaressiD Graveron-Demilly
Jun 12, 2002·Circulation·Lazaros A NikolaidisRichard P Shannon
Jun 12, 2004·American Journal of Physiology. Heart and Circulatory Physiology·Margaret P ChandlerWilliam C Stanley
Jan 29, 2005·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Matthew D RobsonStefan Neubauer
Jul 1, 2005·Physiological Reviews·William C StanleyGary D Lopaschuk
Feb 9, 2006·European Heart Journal·Fausto RigoEugenio Picano
Mar 16, 2007·The New England Journal of Medicine·Stefan Neubauer
Sep 11, 2008·Biochemical and Biophysical Research Communications·Oliver ZolkMartin F Fromm
Nov 22, 2008·NMR in Biomedicine·D J TylerM D Robson
Nov 19, 2009·Circulation. Cardiovascular Imaging·Theodoros D KaramitsosJoseph B Selvanayagam
Aug 17, 2010·Journal of cardiology·Mitsuo SobajimaHiroshi Inoue
Oct 28, 2010·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Cameron J HollowayUNKNOWN Caudwell Xtreme Everest Research Group
Dec 29, 2010·Journal of Cardiac Failure·Fausto RigoRosa Sicari
Jan 20, 2012·Cardiovascular Research·Marion HölscherAnke Zieseniss
May 26, 2012·Journal of the American College of Cardiology·Jayanth R ArnoldJoseph B Selvanayagam
Aug 3, 2012·Circulation. Cardiovascular Imaging·Thomas WalcherPeter Bernhardt
Mar 19, 2013·Journal of the American College of Cardiology·Theodoros D KaramitsosStefan Neubauer
Jul 3, 2013·Circulation·Cameron J HollowayStefan Neubauer
Oct 8, 2013·EMBO Molecular Medicine·Rajan GognaPeriannan Kuppusamy
Dec 18, 2013·Science Translational Medicine·Paul A BottomleyRobert G Weiss
May 2, 2014·Journal of Cardiovascular Magnetic Resonance : Official Journal of the Society for Cardiovascular Magnetic Resonance·Masliza MahmodTheodoros D Karamitsos
Oct 1, 2014·PloS One·Mohammad Nurulqadr JameelJianyi Zhang
Citations
Nov 19, 2015·Circulation. Heart Failure·Jie Zheng, Robert J Gropler
May 19, 2018·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Michael BietenbeckAli Yilmaz
Jul 7, 2017·Echocardiography·Kegan J MoneghettiFrancois Haddad
Jan 20, 2018·Clinical and Experimental Pharmacology & Physiology·Karthigesh Sree RamanJoseph B Selvanayagam
Mar 15, 2019·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·James A HorscroftAndrew J Murray
Dec 3, 2016·Expert Review of Molecular Diagnostics·Harmen G BooijB Daan Westenbrink
May 20, 2020·Scientific Reports·Nikolaj BøghPeter Agger
May 21, 2016·American Journal of Physiology. Heart and Circulatory Physiology·Vincenzo Lionetti
Jun 22, 2018·Frontiers in Cardiovascular Medicine·Qutuba G KarwiGary D Lopaschuk
Jul 28, 2016·Expert Opinion on Therapeutic Patents·Christopher H GeorgeZaheer Yousef
Mar 15, 2019·Echocardiography·Ewelina KowalczykPiotr Lipiec
Sep 19, 2018·Journal of Cardiothoracic Surgery·Sebastian VogtRabia Ramzan
Jan 27, 2021·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Lillian LuJie Zheng
Aug 12, 2021·Current Heart Failure Reports·Elizabeth Hillier, Matthias G Friedrich