No evidence of West Nile virus infection in Dutch blood donors

Vox Sanguinis
Marco H G M KoppelmanH T Cuypers

Abstract

West Nile virus (WNV) can be transmitted by transfusion through infected blood components. This study aimed to determine the prevalence of WNV infection among Dutch blood donors to assess whether WNV is a possible threat for the Dutch blood supply. Plasma samples from 61 992 blood donations were pooled in 7,749 test pools of eight donations using a Tecan robot. These samples were collected between April and October 2004. The pools were tested for the presence of WNV RNA by using the Procleix WNV assay. No WNV RNA-positive pools were detected. Based on Poisson distribution statistics, extrapolation of our data to all the Dutch donations in 2004 revealed that between 0 and 55 cases of WNV infection could be expected. No evidence of the presence of WNV RNA in Dutch blood donor samples from 2004 was found. However, surveillance of this emerging infection is of importance to safeguard the blood supply in the future because the transmission cycle of WNV is complex and hard to predict.

References

Jun 16, 2001·The New England Journal of Medicine·D NashUNKNOWN 1999 West Nile Outbreak Response Working Group
Jan 19, 2002·Annals of the New York Academy of Sciences·A E Platonov
Jan 19, 2002·Annals of the New York Academy of Sciences·B MurgueH G Zeller
Jun 27, 2002·Current Topics in Microbiology and Immunology·B MurgueV Deubel
May 30, 2003·The New England Journal of Medicine·Martha IwamotoUNKNOWN West Nile Virus in Transplant Recipients Investigation Team
Jul 24, 2003·JAMA : the Journal of the American Medical Association·James J SejvarLyle R Petersen
Sep 19, 2003·The Journal of General Virology·Alan BuckleyErnest A Gould
Sep 23, 2003·The New England Journal of Medicine·Lisa N PealerUNKNOWN West Nile Virus Transmission Investigation Team
Jul 21, 2004·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·Roy GuharoyJonathan Ference
Sep 1, 2004·The Lancet Infectious Diseases·Bruno P GranwehrAlan D T Barrett
Oct 2, 2004·Neuroepidemiology·Imed FekiChokri Mhiri
Apr 12, 2005·Transfusion·Steven KleinmanUNKNOWN NHLBI Retrovirus Epidemiology Study (REDS)

❮ Previous
Next ❯

Citations

Jun 8, 2007·Journal of Translational Medicine·Florian BihlChristian Brander
Sep 2, 2009·Transfusion Medicine·M N KantzanouA Hatzakis
Jan 8, 2015·Frontiers in Public Health·Marieta BraksHein Sprong
Apr 19, 2013·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·V SambriM P Landini
Jan 22, 2008·Journal of Medical Virology·Christa PfleidererC Micha Nübling

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.