No evidence of XMRV infection in immunocompromised patients and HIV-positive individuals from Germany.

Infection
K KornA Knöll

Abstract

Xenotropic murine leukaemia virus-related virus (XMRV) has been detected in patients with prostate cancer and chronic fatigue syndrome (CFS). The detection of XMRV in healthy individuals has raised concern about a possible virus transmission by blood products. However, recent studies challenge the association between XMRV and human disease. This study investigated whether or not XMRV is present in patients with altered immune function and individuals at increased risk of blood-borne viral infections in Germany. We investigated 503 peripheral blood mononuclear cell (PBMC) samples from 240 patients with iatrogenic immune suppression (71 haematopoietic stem cell recipients, 132 solid organ transplant recipients, 37 others) and 311 PBMC samples from 302 patients with HIV-1 infection for the presence of proviral XMRV by real-time polymerase chain reaction (PCR). All 814 PBMC samples from 542 patients tested negative for XMRV DNA and positive for an internal herpesvirus saimiri (HVS) control. Human genomic DNA was detected in all samples, and 90% of the samples contained >10,000 cell equivalents per XMRV PCR reaction. Our failure to detect proviral XMRV provides evidence against the presence of XMRV in patients at increased risk of v...Continue Reading

References

Oct 7, 2009·Proceedings of the National Academy of Sciences of the United States of America·Robert SchlabergIla R Singh
Jan 13, 2010·PloS One·Otto ErlweinAnthony Cleare
Sep 3, 2010·Retrovirology·Robert A SmithA Dusty Miller
Oct 6, 2010·BMC Biology·Robin A Weiss
Dec 22, 2010·Retrovirology·Mark J RobinsonMyra O McClure
Dec 22, 2010·Retrovirology·Stéphane HuéGreg J Towers
Jan 18, 2011·Transfusion·Harvey G KleinUNKNOWN AABB Interorganizational Task Force on XMRV
Mar 31, 2011·Retrovirology·Toshie SakumaYasuhiro Ikeda
Jun 2, 2011·Science·Tobias PaprotkaVinay K Pathak

❮ Previous
Next ❯

Citations

Jul 24, 2012·Current Opinion in Virology·Krista Delviks-FrankenberryVinay K Pathak
Jul 31, 2014·Revista Da Sociedade Brasileira De Medicina Tropical·Samara Tatielle Monteiro GomesAntonio Carlos Rosário Vallinoto
Feb 13, 2020·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Simone BertzAntje Knöll

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.