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No evidence that selection has been less effective at removing deleterious mutations in Europeans than in Africans

Nature Genetics

Feb 1, 2015

Ron DoDavid E. Reich

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Abstract

Non-African populations have experienced size reductions in the time since their split from West Africans, leading to the hypothesis that natural selection to remove weakly deleterious mutations has been less effective in the history of non-Africans. To test this hypothesis, we measured...read more

Mentioned in this Paper

Amino Acid Substitution
Genetic Equilibrium
In Silico
Selection, Genetic
Genetics, Population
Neanderthals
African Continental Ancestry Group
Reconcile
European Continental Ancestry Group
Variation (Genetics)
25
1
208
Paper Details
References
    • References24
    • Citations34
    • References24
    • Citations34
  • No evidence that selection has been less effective at removing deleterious mutations in Europeans than in Africans

    Nature Genetics

    Feb 1, 2015

    Ron DoDavid E. Reich

    PMID: 25581429

    DOI: 10.1038/ng.3186

    Abstract

    Non-African populations have experienced size reductions in the time since their split from West Africans, leading to the hypothesis that natural selection to remove weakly deleterious mutations has been less effective in the history of non-Africans. To test this hypothesis, we measured...read more

    Mentioned in this Paper

    Amino Acid Substitution
    Genetic Equilibrium
    In Silico
    Selection, Genetic
    Genetics, Population
    25
    1
    208

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    Paper Details
    References
    • References24
    • Citations34
    • References24
    • Citations34
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