No fever and leucocytosis in response to a lipopolysaccharide challenge in an insectivorous bat

Biology Letters
Sebastian StockmaierM Teague O'Mara

Abstract

Bat immune systems may allow them to respond to zoonotic agents more efficiently than other mammals. As the first line of defence, the taxonomically conserved acute phase immune reaction of leucocytosis and fever is crucial for coping with infections, but it is unknown if this response is a key constituent to bat immunological success. We investigated the acute phase reaction to a standard lipopolysaccharide (LPS) challenge in Pallas's mastiff bats (Molossus molossus). Challenged bats lost mass, but in contrast to other mammals showed no leucocytosis or fever. There also was no influence on body temperature reduction during torpor. When compared to recent genome-wide assays for constituent immune genes, this lack of a conserved fever response to LPS contributes to a clearer understanding of the innate immune system in bat species and of the coevolution of bats with a wide diversity of pathogens.

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Citations

Sep 1, 2016·Annual Review of Virology·David T S Hayman
Jan 9, 2018·Royal Society Open Science·M Teague O'MaraDina K N Dechmann
Jun 20, 2019·The Journal of Social Psychology·Liam CrossSabrina Golonka
Jul 22, 2020·Journal of Experimental Zoology. Part A, Ecological and Integrative Physiology·Gabriel MelhadoAriovaldo P da Cruz-Neto
Jul 17, 2020·Biology Letters·Sebastian StockmaierGerald G Carter
Oct 9, 2018·Frontiers in Immunology·Judith N MandlMichelle L Baker
Oct 17, 2020·Scientific Reports·Christian C VoigtGábor Á Czirják
Apr 21, 2021·Annals of the New York Academy of Sciences·Kelsey R MorenoYossi Yovel
May 29, 2021·Nature Reviews. Microbiology·Elizabeth K Mallott, Katherine R Amato
Jun 10, 2021·The Journal of Experimental Biology·Emily Cornelius RuhsCynthia J Downs

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