PMID: 8964898Apr 1, 1996Paper

No genetic linkage between multiple sclerosis and the interferon alpha/beta locus

Journal of Neuroimmunology
M BergkvistM Sandberg-Wollheim

Abstract

Multiple sclerosis (MS) is probably caused by an interaction of genetic and environmental factors. The genetic component is reflected by a ten-fold higher concordance rate in monozygotic (27%) compared to dizygotic (3%) twin pairs. Treatment with interferon was recently reported to have a favorable effect in patients with relapsing-remitting MS. In the present familial study, we have investigated the possibility of a genetic association between the highly polymorphic Interferon alpha beta locus and the development of MS. Based on our data, we conclude that there is no linkage between the Interferon alpha beta locus and MS.

References

Nov 1, 1992·Human Molecular Genetics·D J Kwiatkowski, M O Diaz
Feb 1, 1990·Annals of Neurology·A NoronhaM A Jensen
Jul 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·M OhlssonA von Gabain
Jun 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·G M LathropJ Ott
Mar 1, 1983·Annals of Neurology·C M PoserW W Tourtellotte
Oct 1, 1994·Journal of Neuroimmunology·G C Ebers, A D Sadovnick
Jan 1, 1994·Neurology·C J MumfordD A Compston
Mar 1, 1993·Annals of Neurology·A D SadovnickT J Murray

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Citations

Oct 25, 2007·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·M NyströmP Sundström
Feb 6, 2004·Multiple Sclerosis : Clinical and Laboratory Research·M BergkvistM Sandberg-Wollheim

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