No Guts, No Loss: Toward the Ideal Treatment for Obesity in the Twenty-First Century

Frontiers in Endocrinology
David C D HopeStephen R Bloom

Abstract

Over the last century, our knowledge of the processes which control appetite and weight regulation has developed significantly. The understanding of where gut hormones fit into the control of energy homeostasis in addition to the rapid advancement of pharmacotherapeutics has paved the way for the development of novel gut hormone analogs to target weight loss. Currently, bariatric surgery remains the most efficacious treatment for obesity. The emergence of gut hormone analogs may provide a useful non-surgical addition to the armamentarium in treating obesity. Simply targeting single gut hormone pathways may be insufficiently efficacious, and combination/multiple-agonist approaches may be necessary to obtain the results required for clear clinical impact.

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Citations

Jun 5, 2020·Biomolecules·Carme Grau-BovéAnna Ardévol
Nov 3, 2020·The Journal of Clinical Endocrinology and Metabolism·Christoffer A HagemannFilip K Knop
Jun 21, 2021·Obesity Research & Clinical Practice·Etika Ratna NoerChia-Hua Kuo
Dec 11, 2021·CPT: Pharmacometrics & Systems Pharmacology·Rolien BoschNelleke Snelder

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Methods Mentioned

BETA
pharmacotherapies
pharmacotherapy
infrared thermometry

Clinical Trials Mentioned

NCT01515319

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