No Increase in Colon Cancer Risk Following Induction with Neu5Gc-Bearing Rabbit Anti-T Cell IgG (ATG) in Recipients of Kidney Transplants

Cancers
Jean-Paul SoulillouGerhard Opelz

Abstract

Because of a mutation of the gene allowing the synthesis of the Neu5Gc form of neuraminidic acid, humans lack the Neu5Gc present in other mammals and develop anti-Neu5Gc. However, humans can absorb dietary Neu5Gc and normal colon epithelium displays minute amounts of Neu5Gc. The potential "physiological" formation of in situ immune complexes has been proposed as a risk factor for colon cancer and as the link between red meat-rich diet and colon carcinoma. In this article, we took advantage of evidence that polyclonal rabbit IgG (ATG) elicits an immune response against Neu5Gc and we consulted a large data base of allograft recipients treated or not with animal-derived IgG to discuss this hypothesis. Based on data from 173,960 and 38,505 patients without and with ATG induction, respectively, we found no evidence that exposure to higher levels of anti-Neu5Gc is associated with a higher incidence of colon carcinoma.

References

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Citations

Sep 27, 2019·Frontiers in Immunology·Anoopjit Singh KoonerXi Chen
Jul 14, 2020·Frontiers in Immunology·Jean-Paul SoulillouJean-Marie Bach
Feb 11, 2020·Frontiers in Immunology·Sharon Yehuda, Vered Padler-Karavani
May 1, 2020·Frontiers in Immunology·Alfred Joseph TectorJean-Marie Bach

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